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dc.contributor.advisorUeda, Jun
dc.contributor.authorLacey, Lauren Elizabeth
dc.date.accessioned2014-05-22T15:32:05Z
dc.date.available2014-05-22T15:32:05Z
dc.date.created2014-05
dc.date.issued2014-04-03
dc.date.submittedMay 2014
dc.identifier.urihttp://hdl.handle.net/1853/51879
dc.description.abstractIn order for stroke subjects to gain functional recovery of their hemiparetic limbs, facilitation techniques such as the repetitive facilitation exercise, or RFE, have been developed. Currently, there is a lack of understanding of the neural mechanisms associated with these types of facilitation techniques. To better understand the neural mechanisms associated with the RFE a functional magnetic resonance imaging (fMRI) study should be conducted. This thesis presents experimental results testing the feasibility of implementing an fMRI-compatible actuator to facilitate a myotatic reflex in synchronization with the subject’s intention to move their hemiparetic limb. Preliminary data from a healthy individual demonstrated the feasibility of overlapping the long latency component of the afferent myotatic reflex, created by electrical stimulation, with descending nerve impulses, created using transcranial magnetic stimulation, in a time window of 15ms. In addition, a pneumatic actuation time delay due to long transmission line was evaluated. The pneumatic actuator met the timing precision requirement for the rehabilitation device for varying transmission line lengths. Therefore a pneumatic actuation system was chosen for the rehabilitation device. This thesis will also presents on the design of an fMRI-compatible pneumatic actuator device to excite a stretch reflex response. Initial, experimental results with the device demonstrated that the designed pneumatic device can control the timing of the muscle response with a fixed signal within the required 15ms window required for cortical facilitation, which was found in the previous feasibility study. However, the device was unable to create a long latency reflex observable at the muscle. Finally, this thesis presents on the capability of the device in creating subthreshold long latency response with precision to overlap with a subthreshold descending nerve impulse, created using transcranial magnetic stimulation. The overlap of the two responses was evaluated by comparing the amplitude of the muscle response with and without the stretch reflex, created by the fMRI-compatible pneumatic actuator device. Varying time delays were analyzed.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectStroke
dc.subjectRehabilitation device
dc.subjectfMRI-compatible
dc.subjectLong latency reflex
dc.subjectHemiparetic
dc.subjectStretch reflex
dc.subjectPneumatics
dc.subject.lcshMedical rehabilitation
dc.subject.lcshMagnetic resonance imaging
dc.subject.lcshActuators
dc.subject.lcshPneumatic control
dc.titleAssessment of repetitive facilitation exercise with fMRI-compatible rehabilitation device for hemiparetic limbs
dc.typeThesis
dc.description.degreeM.S.
dc.contributor.departmentMechanical Engineering
thesis.degree.levelMasters
dc.contributor.committeeMemberBook, Wayne
dc.contributor.committeeMemberShinohara, Minoru
dc.date.updated2014-05-22T15:32:05Z


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