Incorporation of polyoxometalate with gelatin and their feasibility as an anti-cancer drug
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Polyoxometalates (POMs) are a class of transition-metal oxide clusters with significant applications in material science as well as in the biomedical field. Recently, it has been reported that POMs exhibit antitumor activity. POMs containing molybdenum (Mo), tungsten (W), and vanadium (V) with oxygen are three types of POMs with different structural features introduced by our lab as a novel inorganic chemotherapeutic agent for cancer treatment. In this study, Vanadium polyoxometalate (V-POM), which exhibited highest cytotoxicity in 5 different cancer cell lines in in vitro experiment, will be incorporated with Gelatin type B through polymer modification in hopes of prolonging circulation time and avoiding undesired toxicity. The stability, cellular uptake, and cytotoxicity of the V6-POM/Gelatin nanoparticles will be investigated in vitro. The reported study indicates the feasibility of using V6-POM/gelatin nanoparicles for anticancer applications.