Cellular mechanisms of high-frequency alternating current block in peripheral nerves
Stanford, Rachel Shizuka
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High-frequency alternating currents (HFAC) can be applied to nerves to reversibly stop the conduction of signals in peripheral nerves. This can be useful in treating conditions such as chronic pain, inflammation, and neuromuscular pathologies where there is excessive neuronal activity which can cause decreased motor control or painful sensations. However, the cellular mechanisms underlying HFAC block is not well understood. In this study, tetrodotoxin (TTX), a sodium channel blocker whose cellular mechanism is known is utilized to examine the cellular mechanisms of HFAC. We expect low dosages of TTX to alter the threshold of the HFAC required for complete block. Understanding how HFAC induces block can affect how we treat neuropathologies by this technique.