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dc.contributor.authorMcGrath, Patrick
dc.date.accessioned2015-09-09T19:27:41Z
dc.date.available2015-09-09T19:27:41Z
dc.date.issued2015-08-31
dc.identifier.urihttp://hdl.handle.net/1853/53815
dc.descriptionPresented on August 31, 2015 in the Klaus Advanced Computing Building, room 1116W at 3:00 p.m. on the Georgia Tech Campusen_US
dc.descriptionPatrick McGrath is an Assistant Professor in the School of Biology at Georgia Tech.
dc.descriptionRuntime: 52:24 minutes
dc.description.abstractDifferences in DNA sequence between two individuals or cells can cause diseases like autism and cancer. The McGrath lab is interested in understanding how changes in DNA lead to observable differences among individuals of a species. This basic goal has been difficult due to the complexity of the relationship between genotype and phenotype. In order to improve our ability to predict how genetic variants influence reproductive rates in the nematode C. elegans, we are using a mechanistic model of the egg-laying process based upon years of accumulated experiments. This model is able to explain seemingly non-linear interactions between two genetic variants as well as predict the effect age has on the effect of the genetic variant. Application of this model improves our ability to understand how the genetic factors control this trait.en_US
dc.format.extent00:00 minutes
dc.format.extent52:24 minutes
dc.publisherGeorgia Institute of Technologyen_US
dc.relation.ispartofseriesPhysics Colloquiumen_US
dc.subjectDNAen_US
dc.subjectGenetic factorsen_US
dc.subjectGenotypesen_US
dc.subjectPhenotypesen_US
dc.titleUsing Mechanistic Modeling to Understand Non-Linear and Age-Dependent Effects of Genetic Factorsen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Physicsen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Biologyen_US
dc.embargo.termsnullen_US


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