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dc.contributor.authorJo, Hanjoong
dc.date.accessioned2015-09-11T15:54:57Z
dc.date.available2015-09-11T15:54:57Z
dc.date.issued2015-09-08
dc.identifier.urihttp://hdl.handle.net/1853/53817
dc.descriptionPresented on September 8, 2015 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering and Biosciences (IBB), room 1128, Georgia Tech.en_US
dc.descriptionHanjoong Jo, Ph.D. is the John and Jan Portman Professor of Biomedical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and the Division of Cardiology, Emory University.
dc.descriptionFrom Mechanobiology to RNA-based Therapeutics and Nanomedicine: Hanjoong Jo and his lab study how mechanical force associated with blood flow regulates vascular biology and cardiovascular disease, especially atherosclerosis, aortic valve (AV) calcification, and abdominal aortic aneurysms. His lab developed a mouse model of flow-induced atherosclerosis and in vitro shear stress systems to understand the role of flow in endothelial cells and atherosclerosis. Using the animal model, his lab discovered numerous mechanosensitive genes (mRNAs and microRNAs) that are regulated by disturbed flow and their role in atherosclerosis and AV calcification. Recently, his lab has shown that disturbed flow regulates mechanosensitive genes by controlling epigenomic DNA methylation patterns and that inhibition of a key enzyme DNMT by 5-Aza-deoxycytidine can prevent atherosclerosis in mice. His lab has begun taking steps to translate these animal studies toward the clinic by developing better gene and drug therapies using nanotechnology-based delivery approaches and better therapeutic strategies.
dc.descriptionRuntime: 54:55 minutes
dc.format.extent54:55 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.relation.ispartofseriesPetit Institute Breakfast Club Seminar Series
dc.subjectAtherosclerosisen_US
dc.subjectDistrubed flowen_US
dc.subjectEpigeneticsen_US
dc.subjectMechanosensitive genesen_US
dc.subjectTargeted anti‐miR deliveryen_US
dc.titleFrom Mechanosensitive Genes and Epigenetics To Nanomedicine ‐ Going With the Flow to Develop Novel Anti‐atherogenic Therapiesen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Institute for Bioengineering and Bioscienceen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Dept. of Biomedical Engineeringen_US
dc.contributor.corporatenameEmory University. Division of Cardiologyen_US
dc.embargo.termsnullen_US


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