Show simple item record

dc.contributor.authorPardue, Machelle T.
dc.date.accessioned2015-11-11T20:41:17Z
dc.date.available2015-11-11T20:41:17Z
dc.date.issued2015-10-29
dc.identifier.urihttp://hdl.handle.net/1853/54164
dc.description2015 Fall Meeting of the NanoFANS Forum. Presented on October 29, 2015 from 11 a.m.-3 p.m. in the Marcus Nanotechnology Building (Rooms 1116-1118) on the Georgia Tech campus.en_US
dc.descriptionNanoFANS Fall 2015 - Event Focus: Current Trends in Ophthalmology
dc.descriptionDr. Machelle T. Pardue is a Professor of Biomedical Engineering at Georgia Tech and Atlanta VA Medical Center.
dc.descriptionRuntime: 47:10 minutes
dc.description.abstractDiabetic retinopathy (DR) is the leading cause of blindness in adults 20 to 74 years of age. Detecting early stage retinopathy prior to the onset of clinical findings would greatly impact the management and treatment of DR. We have identified several tests that show dysfunction in the retina prior to the onset of clinically‐significant vascular lesions induced by diabetes. We have determine that rod photoreceptor function is most vulnerable to diabetes using novel stimuli with the electroretinogram. Our studies show similar delays in rodent models of diabetes and diabetic patients, prior to clinically diagnosed DR. In addition, we have shown that spatial frequency and contrast sensitivity declines prior to vascular changes when tested with moving gratings. Finally, we have demonstrated that the application of inducible fluorescent tags to detect ROS in the retina, providing another possible screening tool for DR. To determine the mechanisms underlying neuronal dysfunction in early DR, we examined the role of decreased retinal dopamine, a key neuromodulator in the retina. Using our screening tools to detect early disease, we are able to preserve retinal and visual function in diabetic rodents by restoring dopamine levels with L‐DOPA or exercise therapies.en_US
dc.format.extent47:10 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.relation.ispartofseriesNanoFANS Forum
dc.subjectDiabetesen_US
dc.subjectDopamineen_US
dc.subjectExerciseen_US
dc.subjectPreventionen_US
dc.subjectRetinopathyen_US
dc.titleThe Diagnosis and Treatment of Early Stage Diabetic Retinopathyen_US
dc.typePresentationen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Microelectronics Research Centeren_US
dc.contributor.corporatenameGeorgia Institute of Technology. Nanotechnology Research Centeren_US
dc.contributor.corporatenameGeorgia Institute of Technology. Institute for Electronics and Nanotechnologyen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Dept. of Biomedical Engineeringen_US
dc.embargo.termsnullen_US


Files in this item

This item appears in the following Collection(s)

Show simple item record