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dc.contributor.advisorBao, Gang
dc.contributor.authorMasoodzadehgan, Nazanin
dc.date.accessioned2016-01-07T17:20:42Z
dc.date.available2016-01-07T17:20:42Z
dc.date.created2014-12
dc.date.issued2014-08-25
dc.date.submittedDecember 2014
dc.identifier.urihttp://hdl.handle.net/1853/54253
dc.description.abstractEarly stage disease diagnosis still remains a challenge despite much efforts to develop novel imaging and diagnostic techniques. Nanoparticles used as molecular imaging contrast agents with multifunctionality and flexibility provide a platform for targeting the specific disease biomarkers and integration of imaging modalities. In this work, we developed a simplified method for synthesis of radiolabeled targeted super paramagnetic iron oxide nanoparticles (SPIOs). This method takes advantage of the chelator BAT that is conjugated to the PEG before the coating process begins. The effect of nanoparticle size and PEG density was investigated in a series of in vivo experiments. The 64Cu-VINP-SPIOs were used in the PET imaging of inflammation and 64Cu-CD105-SPIOs were used in imaging of 4T1 murine tumor model. In summary, we investigated the potential of the radiolabeled, targeted SPIOs in imaging atherosclerotic plaque and tumor in vivo using magnetic resonance imaging (MRI) and Positron emission tomography (PET). Our results show that dual modality SPIOs with active targeting mediated by affinity ligands can be a great tool in molecular imaging and diagnosis of early stage plaque and tumor.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectSPIO
dc.subjectImaging
dc.subjectDisease
dc.subjectPET/MR
dc.subjectTargeting
dc.subjectDual modality
dc.subjectRadiolabeling
dc.titlePET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS
dc.typeDissertation
dc.description.degreePh.D.
dc.contributor.departmentMechanical Engineering
thesis.degree.levelDoctoral
dc.contributor.committeeMemberRahnema, Farzad
dc.contributor.committeeMemberGoodman, Mark
dc.contributor.committeeMemberTaylor, Robert
dc.contributor.committeeMemberMao, Hui
dc.contributor.committeeMemberLiu, Yongjian
dc.date.updated2016-01-07T17:20:42Z


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