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dc.contributor.advisorCho, Sang H.
dc.contributor.advisorWang, Chris K.
dc.contributor.authorManohar, Nivedh Harshan
dc.date.accessioned2016-05-27T13:10:10Z
dc.date.available2016-05-27T13:10:10Z
dc.date.created2015-05
dc.date.issued2015-04-06
dc.date.submittedMay 2015
dc.identifier.urihttp://hdl.handle.net/1853/54877
dc.description.abstractGold nanoparticles (GNPs) have recently attracted considerable interest for use in radiation therapy due to their unique physical and biological properties. Of interest, GNPs (and other high-atomic-number materials) have been used to enhance radiation dose in tumors by taking advantage of increased photoelectric absorption. This physical phenomenon is well-understood on a macroscopic scale. However, biological outcomes often depend on the intratumoral and even intracellular distribution of GNPs, among other factors. Therefore, there exists a need to precisely visualize and accurately quantify GNP distributions. By virtue of the photoelectric effect, x-ray fluorescence (XRF) photons (characteristic x-rays) from gold can be induced and detected, not only allowing the distribution of GNPs within biological samples to be determined but also providing a unique molecular imaging option in conjunction with bioconjugated GNPs. This work proposes the use of this imaging modality, known as XRF imaging, to develop experimental imaging techniques for detecting and quantifying sparse distributions of GNPs in preclinical settings, such as within small-animal-sized objects, tissue samples, and superficial tumors. By imaging realistic GNP distributions, computational methods can then be used to understand radiation dose enhancement on an intratumoral scale and perhaps even down to the nanoscopic, subcellular realm, elucidating observed biological outcomes (e.g., radiosensitization of tumors) from the bottom-up. Ultimately, this work will result in experimental and computational tools for developing a better understanding of GNP-mediated dose enhancement and associated radiosensitization within the scope of GNP-aided radiation therapy.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectGold nanoparticle
dc.subjectRadiation therapy
dc.subjectX-ray fluorescence
dc.subjectImaging
dc.subjectComputed tomography
dc.subjectDose enhancement
dc.subjectNanotechnology
dc.subjectGold
dc.subjectGold nanoparticle-aided radiation therapy
dc.subjectMonte Carlo method
dc.subjectCancer treatment
dc.titleQuantitative imaging of gold nanoparticle distribution for preclinical studies of gold nanoparticle-aided radiation therapy
dc.typeDissertation
dc.description.degreePh.D.
dc.contributor.departmentMechanical Engineering
thesis.degree.levelDoctoral
dc.contributor.committeeMemberElder, Eric S.
dc.contributor.committeeMemberDeo, Chaitanya S.
dc.date.updated2016-05-27T13:10:10Z


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