Investigation of the Novel Co-receptor RL-TGR in the Study of Aversive Chemoreception in Predatory Fish
Nagle, Maeve Patricia
MetadataShow full item record
Chemical defenses are crucial elements in marine ecological environments. This kind of defense is especially important to sessile and soft-bodied organisms that have limited other options for protecting themselves. The identity of chemoreceptors in predators that react to chemical defenses has been an understudied area with many questions still unanswered. Previous work has determined a 97 amino acid co-receptor named RL-TGR that responds to aversive compounds found in prey organisms. In this study, mutants of the RL-TGR protein were created in order to test its mechanism of ligand binding. A gene expression assay also showed that RL-TGR is expressed at the larval stage of development in zebrafish and is found in all major tissues of the fish. By studying this novel co-receptor, the first of its kind found to respond to marine chemical defenses, a greater understanding of the physiological responses of predatory animals to chemical defenses can be gained.