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dc.contributor.advisorFernandez, Facundo M
dc.contributor.authorPerez, Jose Javier
dc.date.accessioned2016-08-22T12:21:52Z
dc.date.available2016-08-22T12:21:52Z
dc.date.created2016-08
dc.date.issued2016-05-10
dc.date.submittedAugust 2016
dc.identifier.urihttp://hdl.handle.net/1853/55570
dc.description.abstractTransmission-mode direct analysis in real time (TM-DART) is presented as an alternative sampling strategy to traditional methods of sample introduction for DART MS analysis. A custom-designed sample holder was fabricated to rapidly and reproducibly position insecticide-treated nets normal to the ionizing metastable gas stream, enabling transmission of desorbed analyte ions through the holder cavity and into the MS. Introduction of the sample at this fixed geometry eliminates the need for optimizing sample position and allows spectra based on factors such as metastable gas temperature and flow to be systematically evaluated. The results presented here, supported by computational fluid dynamic simulations, demonstrate the effects of these factors on the resulting mass spectra and the potential of this sampling strategy to be used for qualitative and quantitative analyses. Transmission-mode desorption electrospray ionization (TM-DESI) experiments on similar insecticide-treated nets were performed for comparison purposes.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectDirect analysis in real time
dc.subjectDesorption electrospray ionization
dc.subjectMass spectrometry
dc.subjectAmbient ionization
dc.subjectPyrethroid insecticides
dc.subjectBednets
dc.subjectComputational fluid dynamics
dc.titleImproved diret analysis in real time-mass spectrometry sampling for reproducible quantitative analyses
dc.typeThesis
dc.description.degreeM.S.
dc.contributor.departmentChemistry and Biochemistry
thesis.degree.levelMasters
dc.contributor.committeeMemberJanata, Jiri
dc.contributor.committeeMemberSullards, Cameron
dc.date.updated2016-08-22T12:21:52Z


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