Browsing GT Neuro Seminar Series by Title
Now showing items 31-50 of 104
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Flexible Learning and Decision Making in a Changing World
(2020-10-19)Survival requires proper association of reward outcomes to choices and actions that precede them. To learn successfully, however, the brain must constantly adjust how it incorporates each reward feedback because the ... -
From Spikes to Factors: Understanding Large-scale Neural Computations
(2022-04-04)It is widely accepted that human cognition is the product of spiking neurons. Yet even for basic cognitive functions, such as the ability to make decisions or prepare and execute a voluntary movement, the gap between spikes ... -
The functional connectome across spatiotemporal scales: How integrating fMRI and (i)EEG changes our understanding of the human brain
(2021-03-08)The view of human brain function has drastically shifted over the last decade, owing to the observation that the majority of brain activity is intrinsic rather than driven by external stimuli or cognitive demands. Specifically, ... -
A Functional Cortical Network for Sensorimotor Sequence Generation
(2020-01-27)Daniel O'Connor discusses his laboratory’s recent work on the sensorimotor control of complex tongue movements. The brain generates complex sequences of movements that can be flexibly reconfigured in real-time based on ... -
Functional Imaging of the Human Brain: A Window into the Architecture of the Mind
(2019-09-16)The last 20 years of brain imaging research has revealed the functional organization of the human brain in glorious detail, including dozens of cortical regions each of which is specifically engaged in a particular mental ... -
Genetic Dissection of Spinal Circuits Processing Mechanical Itch
(2018-04-02)We have all experienced an itch. It is a modality of somatic sensation defined as an unpleasant sensation associated with the desire to scratch. Itch can be evoked in the skin directly by physical stimuli, such as gentle ... -
Hippocampal Codes in Spatial Memory and Alzheimer’s Disease
(2016-10-31)The hippocampus is essential for both spatial navigation and episodic memory. While decades of research has revealed patterns of neural activity in the hippocampus that represent information about the spatial environment, ... -
How a Fly Sees the World: Optogenetics, Systems ID, and Optophysiology of Visual Flight Control in Drosophila
(2017-11-06)Flies have remarkably high performance visual systems that operate at the physical and physiological limits of seeing their world as they fly through it. Flies use the pattern of panoramic optic flow to stabilize their ... -
How Early-life Experiences Sculpt Brain Circuits to Promote Resilience or Vulnerability: Role of Microglia
(2021-04-19)Resilience or vulnerability to stress-related emotional disorders is governed in part by early-life experiences. Early-life adversity can profoundly impact an individual’s risk for depression, likely by modulating the ... -
How hippocampal memory shapes, and is shaped by, attention
(2020-09-14)Attention modulates what we see and remember. Memory affects what we attend to and perceive. Despite this connection in behavior, little is known about the mechanisms that link attention and memory in the brain. One key ... -
How the Cortex Regulates the Thalamus
(2016-10-17)The thalamus provides sensory information to the cerebral cortex, but the cortex also sends massive input to the thalamus. Top-down corticothalamic projections may allow the cortex to regulate sensory processing by modulating ... -
How to Improve Detection and Treatment of Diabetic Retinopathy
(2017-03-27)Diabetic retinopathy (DR) is the leading cause of blindness in working age adults. DR is clinically diagnosed by late stage vascular changes in the retina. Detecting early stage retinopathy prior to the onset of these ... -
Identifying and Targeting Potential Biomarkers of Motor Dysfunction after Stroke using Non-invasive Neurostimulation and Neuroimaging
(2016-09-19)Up to 80% of stroke survivors have persistent motor impairment of the paretic arm that interferes with performing functional activities and limits activity participation. Stroke can trigger maladaptive changes in the ... -
Imaging the brain at high spatiotemporal resolution
(2019-04-01)Physics has long employed optical methods to probe and manipulate matter on scales from the infinitesimal to the immense. To understand the brain, we need to monitor physiological processes of single synapses as well as ... -
Impact of Seizures in Memory Performance on a NHP Model of Temporal Lobe Epilepsy
(2018-10-22)There is a lot of controversial finding on how epileptic activities (seizures and interictal epileptiform discharge) affect cognition in both animals and humans. Mesial temporal lobe epilepsy (MTLE) is one of the most ... -
Inhibitory Control of Cortical Activity in vivo
(2016-10-24)The cerebral cortex is the largest and most complicated structure of the mammalian brain. The cortex generates many regimes of spontaneous and sensory evoked activity. What are the cellular and circuit mechanisms that ... -
Integrating New Knowledge into a Neural Network without Catastrophic Interference: Computational and Theoretical Investigations in a Hierarchically Structured Environment
(2019-04-15)According to complementary learning systems theory, integrating new memories into a multi-layer neural network without interfering with what is already known depends on interleaving presentation of the new memories with ... -
Investigating the basis of noise-robust object recognition in humans and convolutional neural networks
(2021-11-29)It has been claimed that convolutional neural networks (CNNs) have now achieved human-level performance at object recognition tasks. However, modest changes to the object stimuli or to the viewing conditions can sometimes ...