Browsing GT Neuro Seminar Series by Title
Now showing items 1-20 of 66
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After the Ice Bucket: Thawing Amyotrophic Lateral Sclerosis with Predictive Medicine
(2017-10-16)The prolific 2014 ALS Association’s Ice Bucket Challenge commenced the world-wide dumping of ice water on the heads of courageous supporters to bring awareness and research funding to a lesser-known yet fatal neurodegenerative ... -
Ancestral Remembrances and Descendant Recollections – Multi-generational Studies of Structure and Function in the Nervous System
(2018-03-26)Historical events have generated data indicating that stressors experienced by populations, affect not only the individuals directly exposed to them, but also descendants. Using animal models, our research (and my talk) ... -
Arbitration between Actions and Habits: Cortical Regulators and the Influence of Cocaine
(2018-01-29)Selecting actions based on their consequences is essential to day-to-day function and yet, is impaired in neuropsychiatric diseases like addiction. Goal-directed action selection likely requires the coordinated output of ... -
Biological and Bionic Hands: Natural Neural Coding and Artificial Perception
(2018-01-22)Our ability to manipulate objects dexterously relies fundamentally on sensory signals originating from the hand. To restore motor function with upper-limb neuroprostheses requires that somatosensory feedback be provided ... -
Biophysically Principled Modeling of Human MEG/EEG Signals Reveals Novel Mechanisms and Meaning of Brain Rhythms
(2016-11-28)Magneto- and Electro-encephalography (MEG/EEG) are among the most powerful technologies to non-invasively record large-scale activity from humans with fine temporal and spatial resolution. These signals provide reliable ... -
Bringing Bioelectricity to Light
(2017-02-06)To study a neural circuit, one would like to probe the activity of many neurons, with high resolution in space and time. A key challenge has been the difficulty of visualizing changes in transmembrane potential. We discovered ... -
Cholinergic Sensorimotor Integration Regulates Rapid Behavioral Decisions
(2018-04-16)During active exploration, the spatial and temporal pattern of the sensory cue perceived by an animal is shaped by the animal’s own movement. Thus, to move towards a sensory target, the nervous system needs to make rapid ... -
Cortical Circuits of Vision
(2017-04-24)The diversity of neuron types and synaptic connectivity patterns in the mammalian cerebral cortex is astonishing. How this cellular and synaptic diversity contributes to cortical function is just beginning to emerge. Using ... -
Corticocortical Communication
(2020-02-10)Most brain functions involve neuronal population activity that is distributed across multiple areas. The routing of signals through this distributed network is flexible, changing from moment-to-moment to meet task demands. ... -
Deconstructing Memory Circuits at Cell Type-specific Resolution
(2019-01-28)Nelson Spruston studies the hippocampus, with an emphasis on uncovering the diversity and complexity of cells and synapses that allow this brain structure to contribute to memory-guided behavior, such as spatial navigation ... -
Dissection of Neural Circuit Function and Degeneration from a Subcellular Perspective
(2020-02-17)How do neurons perform the set of signaling functions necessary for proper circuit function? We aim to uncover cellular and molecular mechanisms that shape excitability among different mammalian neurons. We approach these ... -
Distinct Neuronal Ensembles Encode Sensory Stimulus Context in the Neocortex
(2018-11-19)The Hamm lab conducts basic research on cortical microcircuitry with paradigms and approaches designed to provide deeper insight into neuropsychiatric disease. Sensory processing abnormalities in schizophrenia (SZ) undermine ... -
The Dynamics of Perceptual Decision Making
(2017-02-13)How do humans and other animals make decisions? A large body of work has investigated this question in the perceptual domain where subjects make decisions about simple visual stimuli. A critical question concerns the ... -
Effects of Nicotine on Brain and Behavior: How nAChRs Modulate Circuits Related to Mood and Aggression
(2018-03-12)Acetylcholine signaling influences behaviors related to diverse functions, including drug abuse, attention, food intake, and mood. The ability of acetylcholine to coordinate the response of neuronal networks in many brain ... -
Engineering Neurotechnology for the Surgical Treatment of Epilepsy: A Surgeon-scientist-non-engineer’s Perspective
(2018-10-29)(1) Cellular and Gene Therapy for Parkinson’s Disease Elucidation of the role of axon guidance molecules in the development and reconstruction of the nigrostriatal pathway, which degenerates in Parkinson’s Disease, and ... -
Epilepsy – Beyond the Local Network
(2019-10-28)While human research has emphasized the large-scale network disruptions in the epilepsies and their co-morbidities, basic science has typically focused on local networks. In rodents, more general large-scale network dynamics ... -
Evolution and Development of a Minimal Nervous System in our Closest Invertebrate Relatives
(2019-11-25)Animal behavior depends both on the intrinsic properties of individual neurons and how these neurons connect to and modulate one another. A major focus of modern neuroscience is to dissect behavior at the level of individual ... -
Evolutionarily Conserved Mechanisms of Sociality
(2019-10-07)There is an extraordinary amount of variation in social behavior within and across species. However, when phenotypic convergence in behavior (e.g., sociality) is observed, it begs the question as to whether the same neural ... -
Finding Low-dimensional Structure in Large-scale Neural Recordings
(2018-02-12)Improvements in neural recording technologies have rapidly increased the number of neurons that it is now possible to record from. Along with these improvements, analyses of neural information processing are moving from ... -
A Functional Cortical Network for Sensorimotor Sequence Generation
(2020-01-27)Daniel O'Connor discusses his laboratory’s recent work on the sensorimotor control of complex tongue movements. The brain generates complex sequences of movements that can be flexibly reconfigured in real-time based on ...