Browsing GT Neuro Seminar Series by Title
Now showing items 1-20 of 83
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After the Ice Bucket: Thawing Amyotrophic Lateral Sclerosis with Predictive Medicine
(2017-10-16)The prolific 2014 ALS Association’s Ice Bucket Challenge commenced the world-wide dumping of ice water on the heads of courageous supporters to bring awareness and research funding to a lesser-known yet fatal neurodegenerative ... -
Ancestral Remembrances and Descendant Recollections – Multi-generational Studies of Structure and Function in the Nervous System
(2018-03-26)Historical events have generated data indicating that stressors experienced by populations, affect not only the individuals directly exposed to them, but also descendants. Using animal models, our research (and my talk) ... -
Arbitration between Actions and Habits: Cortical Regulators and the Influence of Cocaine
(2018-01-29)Selecting actions based on their consequences is essential to day-to-day function and yet, is impaired in neuropsychiatric diseases like addiction. Goal-directed action selection likely requires the coordinated output of ... -
Biological and Bionic Hands: Natural Neural Coding and Artificial Perception
(2018-01-22)Our ability to manipulate objects dexterously relies fundamentally on sensory signals originating from the hand. To restore motor function with upper-limb neuroprostheses requires that somatosensory feedback be provided ... -
Biophysically Principled Modeling of Human MEG/EEG Signals Reveals Novel Mechanisms and Meaning of Brain Rhythms
(2016-11-28)Magneto- and Electro-encephalography (MEG/EEG) are among the most powerful technologies to non-invasively record large-scale activity from humans with fine temporal and spatial resolution. These signals provide reliable ... -
Brain dynamics related to short-term memory and learning
(2021-02-15)Through the combination of in vivo optical imaging and chronic expression of genetically encoded calcium indicators it is now feasible to directly 'watch' brain activity patterns related to specific behaviors. I will ... -
Bringing Bioelectricity to Light
(2017-02-06)To study a neural circuit, one would like to probe the activity of many neurons, with high resolution in space and time. A key challenge has been the difficulty of visualizing changes in transmembrane potential. We discovered ... -
Cholinergic Sensorimotor Integration Regulates Rapid Behavioral Decisions
(2018-04-16)During active exploration, the spatial and temporal pattern of the sensory cue perceived by an animal is shaped by the animal’s own movement. Thus, to move towards a sensory target, the nervous system needs to make rapid ... -
Cortical Circuits of Vision
(2017-04-24)The diversity of neuron types and synaptic connectivity patterns in the mammalian cerebral cortex is astonishing. How this cellular and synaptic diversity contributes to cortical function is just beginning to emerge. Using ... -
Corticocortical Communication
(2020-02-10)Most brain functions involve neuronal population activity that is distributed across multiple areas. The routing of signals through this distributed network is flexible, changing from moment-to-moment to meet task demands. ... -
Deconstructing Memory Circuits at Cell Type-specific Resolution
(2019-01-28)Nelson Spruston studies the hippocampus, with an emphasis on uncovering the diversity and complexity of cells and synapses that allow this brain structure to contribute to memory-guided behavior, such as spatial navigation ... -
Defining neuromodulation targets for PTSD using neuroimaging
(2021-02-01)Posttraumatic stress disorder (PTSD) is a serious psychiatric condition that affects 6-8% of the general population and 30-46% of military or highly traumatized urban populations. Different neuromodulation techniques are ... -
Dissecting hand dexterity and recovery processes for effective rehabilitation
(2021-04-12)Hand dexterity is the hallmark of human skill and intelligence. From Pablo Casals’ sublime cello playing to the mundane task of tying one’s shoelace, the level of dexterity in humans stands out among our primate relatives. ... -
Dissection of Neural Circuit Function and Degeneration from a Subcellular Perspective
(2020-02-17)How do neurons perform the set of signaling functions necessary for proper circuit function? We aim to uncover cellular and molecular mechanisms that shape excitability among different mammalian neurons. We approach these ... -
Distinct Neuronal Ensembles Encode Sensory Stimulus Context in the Neocortex
(2018-11-19)The Hamm lab conducts basic research on cortical microcircuitry with paradigms and approaches designed to provide deeper insight into neuropsychiatric disease. Sensory processing abnormalities in schizophrenia (SZ) undermine ... -
The Dynamics of Perceptual Decision Making
(2017-02-13)How do humans and other animals make decisions? A large body of work has investigated this question in the perceptual domain where subjects make decisions about simple visual stimuli. A critical question concerns the ... -
Ecological resources and the evolution of parent-offspring interactions
(2020-11-23)Animal behavior is a key component of biological adaptations, where fitness relies on the ability to find mates, acquire food, and avoid predation. Variation in the availability of key ecological resources can drive the ... -
Effects of Nicotine on Brain and Behavior: How nAChRs Modulate Circuits Related to Mood and Aggression
(2018-03-12)Acetylcholine signaling influences behaviors related to diverse functions, including drug abuse, attention, food intake, and mood. The ability of acetylcholine to coordinate the response of neuronal networks in many brain ... -
Engineering Neurotechnology for the Surgical Treatment of Epilepsy: A Surgeon-scientist-non-engineer’s Perspective
(2018-10-29)(1) Cellular and Gene Therapy for Parkinson’s Disease Elucidation of the role of axon guidance molecules in the development and reconstruction of the nigrostriatal pathway, which degenerates in Parkinson’s Disease, and ... -
Epilepsy – Beyond the Local Network
(2019-10-28)While human research has emphasized the large-scale network disruptions in the epilepsies and their co-morbidities, basic science has typically focused on local networks. In rodents, more general large-scale network dynamics ...