Browsing GT Neuro Seminar Series by Title
Now showing items 1-20 of 50
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After the Ice Bucket: Thawing Amyotrophic Lateral Sclerosis with Predictive Medicine
(2017-10-16)The prolific 2014 ALS Association’s Ice Bucket Challenge commenced the world-wide dumping of ice water on the heads of courageous supporters to bring awareness and research funding to a lesser-known yet fatal neurodegenerative ... -
Ancestral Remembrances and Descendant Recollections – Multi-generational Studies of Structure and Function in the Nervous System
(2018-03-26)Historical events have generated data indicating that stressors experienced by populations, affect not only the individuals directly exposed to them, but also descendants. Using animal models, our research (and my talk) ... -
Arbitration between Actions and Habits: Cortical Regulators and the Influence of Cocaine
(2018-01-29)Selecting actions based on their consequences is essential to day-to-day function and yet, is impaired in neuropsychiatric diseases like addiction. Goal-directed action selection likely requires the coordinated output of ... -
Biological and Bionic Hands: Natural Neural Coding and Artificial Perception
(2018-01-22)Our ability to manipulate objects dexterously relies fundamentally on sensory signals originating from the hand. To restore motor function with upper-limb neuroprostheses requires that somatosensory feedback be provided ... -
Biophysically Principled Modeling of Human MEG/EEG Signals Reveals Novel Mechanisms and Meaning of Brain Rhythms
(2016-11-28)Magneto- and Electro-encephalography (MEG/EEG) are among the most powerful technologies to non-invasively record large-scale activity from humans with fine temporal and spatial resolution. These signals provide reliable ... -
Bringing Bioelectricity to Light
(2017-02-06)To study a neural circuit, one would like to probe the activity of many neurons, with high resolution in space and time. A key challenge has been the difficulty of visualizing changes in transmembrane potential. We discovered ... -
Cholinergic Sensorimotor Integration Regulates Rapid Behavioral Decisions
(2018-04-16)During active exploration, the spatial and temporal pattern of the sensory cue perceived by an animal is shaped by the animal’s own movement. Thus, to move towards a sensory target, the nervous system needs to make rapid ... -
Cortical Circuits of Vision
(2017-04-24)The diversity of neuron types and synaptic connectivity patterns in the mammalian cerebral cortex is astonishing. How this cellular and synaptic diversity contributes to cortical function is just beginning to emerge. Using ... -
Deconstructing Memory Circuits at Cell Type-specific Resolution
(2019-01-28)Nelson Spruston studies the hippocampus, with an emphasis on uncovering the diversity and complexity of cells and synapses that allow this brain structure to contribute to memory-guided behavior, such as spatial navigation ... -
Distinct Neuronal Ensembles Encode Sensory Stimulus Context in the Neocortex
(2018-11-19)The Hamm lab conducts basic research on cortical microcircuitry with paradigms and approaches designed to provide deeper insight into neuropsychiatric disease. Sensory processing abnormalities in schizophrenia (SZ) undermine ... -
The Dynamics of Perceptual Decision Making
(2017-02-13)How do humans and other animals make decisions? A large body of work has investigated this question in the perceptual domain where subjects make decisions about simple visual stimuli. A critical question concerns the ... -
Effects of Nicotine on Brain and Behavior: How nAChRs Modulate Circuits Related to Mood and Aggression
(2018-03-12)Acetylcholine signaling influences behaviors related to diverse functions, including drug abuse, attention, food intake, and mood. The ability of acetylcholine to coordinate the response of neuronal networks in many brain ... -
Engineering Neurotechnology for the Surgical Treatment of Epilepsy: A Surgeon-scientist-non-engineer’s Perspective
(2018-10-29)(1) Cellular and Gene Therapy for Parkinson’s Disease Elucidation of the role of axon guidance molecules in the development and reconstruction of the nigrostriatal pathway, which degenerates in Parkinson’s Disease, and ... -
Finding Low-dimensional Structure in Large-scale Neural Recordings
(2018-02-12)Improvements in neural recording technologies have rapidly increased the number of neurons that it is now possible to record from. Along with these improvements, analyses of neural information processing are moving from ... -
Genetic Dissection of Spinal Circuits Processing Mechanical Itch
(2018-04-02)We have all experienced an itch. It is a modality of somatic sensation defined as an unpleasant sensation associated with the desire to scratch. Itch can be evoked in the skin directly by physical stimuli, such as gentle ... -
Hippocampal Codes in Spatial Memory and Alzheimer’s Disease
(2016-10-31)The hippocampus is essential for both spatial navigation and episodic memory. While decades of research has revealed patterns of neural activity in the hippocampus that represent information about the spatial environment, ... -
How a Fly Sees the World: Optogenetics, Systems ID, and Optophysiology of Visual Flight Control in Drosophila
(2017-11-06)Flies have remarkably high performance visual systems that operate at the physical and physiological limits of seeing their world as they fly through it. Flies use the pattern of panoramic optic flow to stabilize their ... -
How the Cortex Regulates the Thalamus
(2016-10-17)The thalamus provides sensory information to the cerebral cortex, but the cortex also sends massive input to the thalamus. Top-down corticothalamic projections may allow the cortex to regulate sensory processing by modulating ... -
How to Improve Detection and Treatment of Diabetic Retinopathy
(2017-03-27)Diabetic retinopathy (DR) is the leading cause of blindness in working age adults. DR is clinically diagnosed by late stage vascular changes in the retina. Detecting early stage retinopathy prior to the onset of these ... -
Identifying and Targeting Potential Biomarkers of Motor Dysfunction after Stroke using Non-invasive Neurostimulation and Neuroimaging
(2016-09-19)Up to 80% of stroke survivors have persistent motor impairment of the paretic arm that interferes with performing functional activities and limits activity participation. Stroke can trigger maladaptive changes in the ...