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    Heterocyclic Peptide Ketoamides

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    8518885.pdf (1.388Mb)
    Date
    8/27/2013
    Author
    Powers, James C.
    Glass, Jonathan D.
    Ovat, Asli
    Li, Zhaozhao
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    Abstract
    A novel class of peptide α-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-AA1-CO—NH--(CH₂)n--R₃. Processes for the synthesis of peptidyl α-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.
    URI
    http://hdl.handle.net/1853/56796
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