Heterocyclic Peptide Ketoamides

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Date
8/27/2013Author
Powers, James C.
Glass, Jonathan D.
Ovat, Asli
Li, Zhaozhao
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Show full item recordAbstract
A novel class of peptide α-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-AA1-CO—NH--(CH₂)n--R₃. Processes for the synthesis of peptidyl α-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.
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- Georgia Tech Patents [1761]