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    Microneedle Devices And Methods Of Manufacture And Use Thereof

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    8708966.pdf (1.222Mb)
    Date
    4/29/2014
    Author
    Allen, Mark G.
    Prausnitz, Mark R.
    Mcallister, Devin V.
    Cros, Florent Paul Marcel
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    Abstract
    Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
    URI
    http://hdl.handle.net/1853/56876
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