Peptides Ketoamides

Abstract

A novel class of peptide α-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M1 -AA-NH--CHR2 --CO--CO--NR3 R4, M1 -AA2 -AA1 -CO--NR3 R4, M1 -AA-AA-AA-CO--NR3 R4, M1 -AA-AA-AA-AA-CO--NR3 R4, or M1 -AA-CO--NR3 R4.