Tetrapeptide ?-ketoamides

Abstract

A novel class of tetrapeptide ?-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M1 --AA1 --AA2 --AA3 --AA4 --CO--NR3 R4.