Use Of Aminoalkyl Phenyl Sulfide Derivatives For The Treatment Of Hypertension

Abstract

Hypertension in mammals can be treated by administering an effective amount of an aminoalkyl phenyl sulfide having the formula wherein (Cₙ H₂ₙ)=a linear or branched alkyl chain of 10 carbons or less (n=1-10); R₁, R₂, R₃, R₄, R₅,=H, OH, C₁ -C4 -alkyl, C₁ -C₄ -alkoxy, F, Cl, Br, or I; R₆ R₇ =H, C₁ -C₄ -alkyl;and the pharmaceutically acceptable salts thereof. The hypotensive potential of the compounds may be evaluated by oxygenation with dopamine-beta-hydroxylase.