Non-peptide Macrocyclic Histone Deacetylase (HDAC) Inhibitors And Methods Of Making And Using Thereof

Abstract

Compounds of Formula I or II, and methods of making and using thereof, are described herein. M represents a macrolide subunit,n is a C1-6 group, optionally containing one or more heteroatoms,D is an alkyl or aryl group,A is a linking group connected to D,B is an alkyl, alkylaryl or alkylheteroaryl spacer group,ZBG is a Zinc Binding Group,R1, R2 and R4 are independently are selected from hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkanoate group, a C2-6 carbamate group, a C2-6 carbonate group, a C2-6 carbamate group, or a C2-6 thiocarbamate group,R3 is hydrogen or -OR5,R5 is selected from a group consisting of Hydrogen, a C1-6 alkyl hgroup, a C2-6 alkenyl group, a C2-6 alkynyl group, C1-6 alkanoate group, C2-6 carbamate group, C2-6 carbonate group, C2-6 carbamate group, or C2-6 thiocarbamate group.