• Login
    View Item 
    •   SMARTech Home
    • Georgia Tech Theses and Dissertations
    • Georgia Tech Theses and Dissertations
    • View Item
    •   SMARTech Home
    • Georgia Tech Theses and Dissertations
    • Georgia Tech Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Exploiting the oxidizing capabilities of laccases for sustainable chemistry

    Thumbnail
    View/Open
    CANNATELLI-DISSERTATION-2017.pdf (3.995Mb)
    Date
    2017-04-05
    Author
    Cannatelli, Mark Daniel
    Metadata
    Show full item record
    Abstract
    Enzyme catalyzed processes are rapidly becoming a viable means to accomplish chemical transformations in the field of synthetic chemistry. In an era where concern about the current and future state of the environment is at its peak, biocatalysts offer many advantages over conventional chemical catalysts, such as being nontoxic, renewable, biodegradable, highly selective, and highly active and stable in aqueous solvents at ambient temperature and neutral pH. Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are a class of multi-copper oxidases that have received increasing use in recent decades as green catalytic oxidants within a variety of industries, including pulp and paper, textiles, food, cosmetics, and pharmaceuticals to name a few. They selectively oxidize electron-rich substrates, such as phenols, anilines, and benzenethiols, while concomitantly catalyzing the four electron reduction of O2 to 2H2O. Within the field of organic synthesis, laccases have been employed to catalyze a multitude of radical-radical coupling, cross-coupling, and domino reactions for the synthesis of new and existing compounds. This dissertation research has focused on harnessing the ability of laccases to generate ortho- and para-quinones in situ from the corresponding catechols and hydroquinones, respectively, which are then able to react with a variety of nucleophiles to form C-C, C-N, and C-S bonds. The developed methods have been employed for the synthesis of fine chemicals and novel lignin-derived biomaterials.
    URI
    http://hdl.handle.net/1853/58293
    Collections
    • Georgia Tech Theses and Dissertations [23403]
    • School of Chemistry and Biochemistry Theses and Dissertations [1509]

    Browse

    All of SMARTechCommunities & CollectionsDatesAuthorsTitlesSubjectsTypesThis CollectionDatesAuthorsTitlesSubjectsTypes

    My SMARTech

    Login

    Statistics

    View Usage StatisticsView Google Analytics Statistics
    facebook instagram twitter youtube
    • My Account
    • Contact us
    • Directory
    • Campus Map
    • Support/Give
    • Library Accessibility
      • About SMARTech
      • SMARTech Terms of Use
    Georgia Tech Library266 4th Street NW, Atlanta, GA 30332
    404.894.4500
    • Emergency Information
    • Legal and Privacy Information
    • Human Trafficking Notice
    • Accessibility
    • Accountability
    • Accreditation
    • Employment
    © 2020 Georgia Institute of Technology