Diiodocallophycoic Acid: A Novel Case of Structural Diversity in Marine Natural Products
Brumley, David Anderson
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Chemical investigations of the chemistry of Fijian reef systems have yielded the discovery of an iodinated diterpene-benzoate produced by the Fijian red macroalga Callophycus sp. Through the use of bioassay guided fractionation, NMR and mass spectrometric-based structural elucidation, diiodocallophycoic acid (1) was successfully isolated and structurally characterized. This novel secondary metabolite was found to contain two highly unusual exocyclic iodinated olefins and demonstrated moderate biological activity against methicillin resistant Staphylococcus aureus (MRSA) with an MIC of 3.9 μg/mL.