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dc.contributor.authorPallas, Sarah
dc.date.accessioned2017-11-03T19:31:03Z
dc.date.available2017-11-03T19:31:03Z
dc.date.issued2017-10-30
dc.identifier.urihttp://hdl.handle.net/1853/58870
dc.descriptionPresented on October 30, 2017 at 11:15 a.m. in the Krone Engineered Biosystems Building, Room 1005.en_US
dc.descriptionSarah Pallas is a professor in Biology and Neuroscience at Georgia State University. She specializes in developmental neuroscience and sensory neurophysiology.en_US
dc.descriptionRuntime: 60:21 minutesen_US
dc.description.abstractResearch in the Pallas lab is aimed at understanding the cellular and molecular mechanisms underlying development and plasticity of sensory pathways in the brain. Our approach is to alter normal developmental programs, either through sensory deprivation or surgical alteration, and study how the neural circuits compensate for the alterations. We have discovered that at both the cortical and subcortical levels, circuits in sensory pathways exhibit remarkable levels of compensatory plasticity. By studying how circuits can be rewired and how excitatory and inhibitory synapses respond, we have demonstrated that inhibitory synaptic plasticity is much more significant than previously appreciated. We are currently investigating how the axon guidance factor ephrin-A and the neurotrophic factor BDNF are involved in orchestrating these plastic responses. Understanding the mechanisms underlying compensatory plasticity is necessary in order to harness them for therapeutic purposes.en_US
dc.format.extent60:21 minutes
dc.language.isoen_USen_US
dc.relation.ispartofseriesGTNeuro Seminar Seriesen_US
dc.subjectCritical period plasticityen_US
dc.subjectSensory deprivationen_US
dc.subjectSynaptic plasticityen_US
dc.subjectTraumatic brain injuryen_US
dc.titleThe Self-Repairing Brain: Mechanisms Underlying Plasticity in Sensory Pathways?en_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Neural Engineering Centeren_US
dc.contributor.corporatenameGeorgia State University. Neuroscience Instituteen_US


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