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dc.contributor.authorPicciotto, Marina
dc.date.accessioned2018-03-16T19:51:58Z
dc.date.available2018-03-16T19:51:58Z
dc.date.issued2018-03-12
dc.identifier.urihttp://hdl.handle.net/1853/59425
dc.descriptionPresented on March 12, 2018 at 11:15 a.m. in the Krone Engineered Biosystems Building, Room 1005.en_US
dc.descriptionDr. Picciotto is the Charles B. G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacologyat Yale University.en_US
dc.descriptionRuntime: 64:51 minutesen_US
dc.description.abstractAcetylcholine signaling influences behaviors related to diverse functions, including drug abuse, attention, food intake, and mood. The ability of acetylcholine to coordinate the response of neuronal networks in many brain areas makes cholinergic modulation an essential mechanism underlying complex behaviors. Interestingly, increasing acetylcholine signaling using pharmacological or genetic methods can induce symptoms related to anxiety and depression in humans and in rodent models. Studies of anxiety- and depression-like behaviors in mice have identified specific cholinergic receptors and brain areas that are necessary for ACh effects. In addition, mouse studies have identified interactions between ACh and monoamine neurotransmitters that are targeted by most antidepressant medications that are effective in human patients. These studies suggest that abnormalities in the cholinergic system may be critical for the etiology of mood disorders and could represent a novel endophenotype of depression that could be targeted to develop novel antidepressant medications. Thus, ACh signaling could contribute to the balance between adaptive responses to stress and mood disorders.en_US
dc.format.extent64:51 minutes
dc.language.isoen_USen_US
dc.relation.ispartofseriesGTNeuro Seminar Seriesen_US
dc.subjectAcetylcholineen_US
dc.subjectBrain functionen_US
dc.subjectNeuroscienceen_US
dc.subjectNicotineen_US
dc.titleEffects of Nicotine on Brain and Behavior: How nAChRs Modulate Circuits Related to Mood and Aggressionen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Neural Engineering Centeren_US
dc.contributor.corporatenameYale University. Dept. of Psychiatryen_US


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