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dc.contributor.authorDuan, Bo
dc.date.accessioned2018-04-09T19:05:56Z
dc.date.available2018-04-09T19:05:56Z
dc.date.issued2018-04-02
dc.identifier.urihttp://hdl.handle.net/1853/59513
dc.descriptionPresented on April 2, 2018 at 11:15 a.m. in the Krone Engineered Biosystems Building, Room 1005.en_US
dc.descriptionBo Duan is an Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at the University of Michigan. The Duan lab uses a combination of mouse genetics, histochemistry, neuroanatomical tracing, electrophysiology, in vivo imaging and behavior analyses to gain understanding of the development, organization, and function of neural circuits that underlie a variety of somatosensory modalities, such as pain and itch.en_US
dc.descriptionRuntime: 49:29 minutesen_US
dc.description.abstractWe have all experienced an itch. It is a modality of somatic sensation defined as an unpleasant sensation associated with the desire to scratch. Itch can be evoked in the skin directly by physical stimuli, such as gentle touch, referred as mechanical itch, or by chemical mediators, such as histamine, referred as chemical itch. Mechanical itch was first described in healthy human subjects by Edward Titchener in 1909 that itch points were found in the skin by punctate stimulation with a fine hair. Under pathological conditions, mechanical itch is one of the common symptoms of most patients with chronic itch. In last decades, the neural circuits that transmit chemical itch have been well studied. The neural circuits processing mechanical itch, however, remain still unknown. My lab uses a combination of intersectional genetic manipulations, electrophysiology and behavior analyses to identify the key components of the spinal circuitry for mechanical itch in mice.en_US
dc.format.extent49:29 minutes
dc.language.isoen_USen_US
dc.relation.ispartofseriesGTNeuro Seminar Seriesen_US
dc.subjectChronic itchen_US
dc.subjectDorsal spinal corden_US
dc.subjectExcitatory interneuronen_US
dc.subjectMechanical itchen_US
dc.titleGenetic Dissection of Spinal Circuits Processing Mechanical Itchen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Neural Engineering Centeren_US
dc.contributor.corporatenameUniversity of Michigan. Dept of Molecular, Cellular and Developmental Biologyen_US


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