• Login
    View Item 
    •   SMARTech Home
    • Georgia Tech Theses and Dissertations
    • Georgia Tech Theses and Dissertations
    • View Item
    •   SMARTech Home
    • Georgia Tech Theses and Dissertations
    • Georgia Tech Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effect of respiration, exercise, and pulsatility on in vitro Fontan hemodynamics

    Thumbnail
    View/Open
    TREE-DISSERTATION-2017.pdf (64.55Mb)
    CHOP11B FB Puls.mp4 (6.122Mb)
    CHOP11B BH Puls.mp4 (1.682Mb)
    CHOP235A FB Puls.mp4 (14.16Mb)
    CHOP235A EX Puls Peak.mp4 (4.902Mb)
    CHOP235A EX Puls Half-Peak.mp4 (4.902Mb)
    CHOP235A BH Puls.mp4 (2.831Mb)
    CHOP235A BH Low Puls.mp4 (2.827Mb)
    CHOP235A BH High Puls.mp4 (2.149Mb)
    CHOP11B EX Puls Peak.mp4 (5.687Mb)
    CHOP11B EX Puls Half-Peak.mp4 (4.021Mb)
    CHOP11B BH Low Puls.mp4 (2.077Mb)
    CHOP11B BH High Puls.mp4 (2.610Mb)
    Date
    2017-03-29
    Author
    Tree, Michael
    Metadata
    Show full item record
    Abstract
    The Fontan procedure is the current intervention for single ventricle congenital heart defect patients. Eventually, all Fontan patients suffer long-term complications. These comorbidities are associated with blood fluid dynamics (hemodynamics) within the Fontan surgical connection. Numerous in vitro studies explore the effects of different patient conditions (breath-held, free-breathing, exercise, etc.) on Fontan hemodynamics. However, none of these studies are conducted with a flexible wall Fontan connection model. The purpose of this study was to develop a flexible Fontan connection model and examine the effect of patient condition on Fontan connection hemodynamics. The study employed model verification, bulk hemodynamic measurement, particle image velocimetry, and computational methods to explore the effects of respiration, exercise, and pulsatility on Fontan hemodynamics. Development resulted in a patient-specific compliance-verified in vitro Fontan circulation model. The model was then used to find the apparent power loss, viscous dissipation, and hepatic flow distribution of the Fontan connection under both physiological and derived experimental conditions. The study found respiration consistently increased apparent power loss. Increasing exercise intensity also increased apparent power loss; the indexed viscous dissipation term also increased with increasing exercise intensity. Increasing pulsatility increased apparent power loss monotonically, but viscous dissipation showed a consistent non-monotonic relationship. This relationship is explained using the Womersley parameter. Power loss and viscous dissipation are further compared, concluding that viscous dissipation is a superior hemodynamic metric. Hepatic flow distribution showed no consistent trends due to respiration, exercise, or pulsatility effects. The time-resolved three-dimensional velocity fields acquired to compute the metrics are useful for computational fluid dynamics simulation verification.
    URI
    http://hdl.handle.net/1853/59775
    Collections
    • Georgia Tech Theses and Dissertations [23877]
    • School of Mechanical Engineering Theses and Dissertations [4086]

    Browse

    All of SMARTechCommunities & CollectionsDatesAuthorsTitlesSubjectsTypesThis CollectionDatesAuthorsTitlesSubjectsTypes

    My SMARTech

    Login

    Statistics

    View Usage StatisticsView Google Analytics Statistics
    facebook instagram twitter youtube
    • My Account
    • Contact us
    • Directory
    • Campus Map
    • Support/Give
    • Library Accessibility
      • About SMARTech
      • SMARTech Terms of Use
    Georgia Tech Library266 4th Street NW, Atlanta, GA 30332
    404.894.4500
    • Emergency Information
    • Legal and Privacy Information
    • Human Trafficking Notice
    • Accessibility
    • Accountability
    • Accreditation
    • Employment
    © 2020 Georgia Institute of Technology