School of Chemical and Biomolecular Engineering Theses and Dissertations
In partial fulfillment of the requirements for a graduate degree in the School of Chemical and Biomolecular Engineering.
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Recent Submissions
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Catalytic Fundamentals of Aqueous Phase Reforming: A Spectroscopic Approach
(Georgia Institute of Technology, 2022-12-07)Hydrogen is an essential commodity for a sustainable chemical industry. Aqueous phase reforming (APR) is a catalytic process that converts polyols (CxH2x+2Ox) derived from biomass into H2 and CO2. However, H2 yields severely ... -
Thermodynamic and Kinetic Investigation of Depsipeptide Oligomerization and Degradation Under Prebiotic Earth Conditions
(Georgia Institute of Technology, 2022-07-28)The formation of polypeptides on the early Earth has been a long-standing problem in the field of prebiotic chemistry. Although it is generally accepted that amino acids were present on the prebiotic Earth based on the ... -
Surface Reactions of Biomass Derived Oxygenates on Lewis Acidic Metal Oxides
(Georgia Institute of Technology, 2021-12-13)Lignocellulosic biomass is currently the only source of organic carbon making it a sustainable source for production of liquid hydrocarbon fuels. One main challenge for valorization of biomass is reducing the oxygen content ... -
Engineered Multifunctional Mesoporous Silica Materials for Cooperative and Cascade Catalysis
(Georgia Institute of Technology, 2022-05-05)Cascade catalysis is the process where multiple synthetic transformations are catalyzed in a one-pot procedure. Cooperatively catalyzed reactions are those where multiple catalyst structures work to offer enhanced rates ... -
Surface Engineering of Protein Nanoclusters to Overcome Mucus Barriers
(Georgia Institute of Technology, 2021-11-01)Intranasal delivery of vaccines is a needle-free route that can induce mucosal antibodies and cellular responses to neutralize pathogens before entering systemic circulation, as well as systemic immunity. However, nasal ... -
Machine-learning models for analysis of biomass reactions and prediction of reaction energies
(Georgia Institute of Technology, 2021-11-22)Biomass and derived compounds have the potential to form the basis of a sustainable economy by providing a renewable source of many chemicals. The selective synthesis and conversion of biomass compounds are often catalyzed ... -
Engineering Carriers for Therapeutic Protein Delivery to Intracellular Targets
(Georgia Institute of Technology, 2021-08-25)Over the past several decades, advances in recombinant DNA technology and protein engineering have led to the use of protein therapeutics in the treatment of many diseases. Despite their many benefits, protein therapeutics ... -
Investigation Of Catalytic Sorbents For Capture And Conversion Of CO2 To Methane
(Georgia Institute of Technology, 2021-08-26)The goal of this thesis is to develop dual function materials (DFM), or a catalytic sorbent, that has higher CO2 sorption and CO2 hydrogenation (methanation) capacities than currently existing materials and study fundamentals ... -
Engineering Systems of Anti-Repressors for Next-Generation Transcriptional Programming
(Georgia Institute of Technology, 2021-08-13)The ability to control gene expression in more precise, complex, and robust ways is becoming increasingly relevant in biotechnology and medicine. Synthetic biology has sought to accomplish such higher-order gene regulation ... -
TRANSIENT AND MECHANICAL PROPERTIES OF POLY(PHTHALALDEHYDE) AND THE VARIABLE FREQUENCY MICROWAVE CURING OF HIGH-PERFORMANCE THERMOSETS
(Georgia Institute of Technology, 2022-08-08)Research presented in this thesis is split into two parts. The first section involves tuning the transient and mechanical properties of poly(phthaldehyde) to form a flexible, liquefiable transient material that can ... -
Use solid-state NMR to study the molecular structures of disease-associated peptide aggregates
(Georgia Institute of Technology, 2022-08-01)Our lab uses solid-state nuclear magnetic resonance (ssNMR) to characterize the molecular structures of different types of aggregates formed by disease-associated proteins or peptides. In this thesis, we study three aggregate ... -
Analysis of Nanomaterial Physiochemical Property Influences on Lymph Node Accumulation and Leukocyte Association
(Georgia Institute of Technology, 2022-07-29)Lymph nodes house high concentrations of immune cells, and are critical tissues for regulating and priming the adaptive immune response. Thus, these tissues are an important therapeutic target for treatments that modulate ... -
ICAM-1 Targeted Delivery and Biodistribution of Protein Nanoparticles
(Georgia Institute of Technology, 2022-07-20)Inflammation is a regulated response to injury or infection that protects and repairs the body. When an inflammatory response is unregulated, hyper-inflammation can lead to organ damage and endothelium dysfunction. Recently, ... -
MODELING PROTON EXCHANGE MEMBRANE FUEL CELL CATHODE CATALYST LAYERS WITH THE LATTICE BOLTZMANN METHOD-DIRECT NUMERICAL SIMULATION FRAMEWORK
(Georgia Institute of Technology, 2022-07-08)One of the main challenges affecting study of the cathode catalyst layer (CCL) in proton exchange membrane fuel cells (PEMFCs) is the lack of detailed understanding of species transport and how it affects electrochemical ... -
Synthesis, Properties, and Assemblies of Uniform Polymer-ligated Nanocrystals
(Georgia Institute of Technology, 2022-06-21)Colloidal synthesis represents one of the most widely used strategies to produce inorganic nanocrystals for a variety of applications in optoelectronics, catalysis, biotechnology, among other areas. Despite significant ... -
Engineered Nanotechnology for the Delivery of Cancer Immunotherapies to Lymph Nodes to Modulate Anti-Tumor T Cell Immunity
(Georgia Institute of Technology, 2022-06-02)The advent of immunotherapies, particularly immune checkpoint blockade (ICB) monoclonal antibodies (mAbs), to treat advanced cancers has drastically improved outcomes for some patients. These ICB mAbs work by blocking ... -
A Unified Framework for Data-Driven Atomistic Modeling
(Georgia Institute of Technology, 2021-08-06)With the advancements in computers, atomistic modeling has grown to be an important tool in many fields of science in recent decades. This work focuses on two important and popular classes of atomistic modeling methods: ... -
Engineering Viral Protein Antigens That Direct the Humoral Immune Response to Conserved Epitopes
(Georgia Institute of Technology, 2021-08-02)Vaccines are considered to be one of the most cost-effective health interventions for infectious disease. A challenge in the development of an effective vaccine is the creation of an immunogen that elicits a broad immune ... -
Polymer Membranes for the Separation of Complex Natural Hydrocarbon Feeds
(Georgia Institute of Technology, 2021-08-02)Polymer Membranes for the Separation of Complex Natural Hydrocarbon Feeds Ronita Mathias 231 Pages Directed by Dr. Ryan P. Lively The separation of complex liquid mixtures, which are mixtures without a clear singular ... -
Fundamentals of Mechanocatalysis for Lignin Valorization
(Georgia Institute of Technology, 2021-06-08)Lignin, the largest natural source of aromatics, is an appealing sustainable feedstock for many chemicals and materials. The depolymerization of lignin to mono-aromatics has remained challenging and industrial applications ...
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