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dc.contributor.authorSaleh, Omar
dc.date.accessioned2018-06-01T16:41:10Z
dc.date.available2018-06-01T16:41:10Z
dc.date.issued2018-04-19
dc.identifier.urihttp://hdl.handle.net/1853/59979
dc.descriptionPresented at the Symposium on Soft Matter Forefronts, April 19, 2018, from 11:50 a.m.-12:30 p.m. at the Marcus Nanotechnology Building, Rooms 1116-1118, Georgia Tech.en_US
dc.descriptionChairs: Michael Tennenbaum & Alberto Fernandez-Nieves (Georgia Tech).en_US
dc.descriptionOmar Saleh is with the University of California, Santa Barbara.en_US
dc.descriptionRuntime: 42:04 minutesen_US
dc.description.abstractBiomolecules can self-assemble into liquid phases, termed ‘membraneless organelles’ in the biological context, though also known as ‘coacervates’. I will discuss our efforts to study this by exploiting DNA nanotechnology to create DNA particles that phase separate into liquids. Formation of liquids, rather than gel aggregates, depends sensitively on the internal flexibility of the DNA particles. Our engineered system displays unusual properties, including the ability to create several distinct liquid phases in a single solution, and to tailor interactions between the phases. Further, the reduced valency of the particles, along with the relatively stiff nature of the constituent DNA strands, causes the liquid to be extraordinarily sparse, with a DNA volume fraction of only ~2%. This opens the possibility to activate the material by infusion of the liquid with proteins; I will discuss our initial attempts at doing this.en_US
dc.description.sponsorshipGeorgia Institute of Technology. College of Sciencesen_US
dc.description.sponsorshipGeorgia Institute of Technology. Institute for Materialsen_US
dc.description.sponsorshipGeorgia Institute of Technology. Parker H. Petit Institute for Bioengineering and Bioscienceen_US
dc.description.sponsorshipGeorgia Institute of Technology. School of Materials Science and Engineeringen_US
dc.description.sponsorshipGeorgia Institute of Technology. School of Physicsen_US
dc.description.sponsorshipAmerican Physical Societyen_US
dc.description.sponsorshipExxon Mobil Corporationen_US
dc.description.sponsorshipNational Science Foundation (U.S.)en_US
dc.format.extent42:04 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectBiomoleculesen_US
dc.subjectDNA particlesen_US
dc.subjectMembraneless organellesen_US
dc.subjectNanotechnologyen_US
dc.subjectSoft matteren_US
dc.titleSelf–Assembled DNA Liquids: Properties and Protein Activationen_US
dc.typePresentationen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Center for the Science and Technology of Advanced Materials and Interfacesen_US
dc.contributor.corporatenameUniversity of California, Santa Barbaraen_US


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