The Wallace H. Coulter Department of Biomedical Engineering (BME)
The role of the biomedical engineer is to provide answers to problems arising from the study of living systems by employing the methodology and principles of engineering. We are now embarking on the Biomedical Century, and the need for engineers trained in biomedicine is increasing at a tremendous pace.
In September 1997, after an intense planning and review process that involved faculty from both institutions, Georgia Tech joined with Emory University School of Medicine to establish The Wallace H. Coulter Department of Biomedical Engineering (BME).
All materials in SMARTech are protected under U.S. Copyright Law and all rights are reserved. Such materials may be used, quoted or reproduced for educational purposes only with prior permission, provided proper attribution is given. Any redistribution, reproduction or use of the materials, in whole or in part, is prohibited without prior permission of the author.
Sub-communities within this community
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Department of Biomedical Engineering Seminars, Symposia, and Workshops [9]
Seminars, Symposia, and Workshops hosted by the The Wallace H. Coulter Department of Biomedical Engineering
Collections in this community
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Biomedical Engineering Technical Reports [32]
Papers and articles produced by Dr. Brani Vidakovic's research -
Biomedical Imaging Lab (Minerva Research Group) [210]
Research produced by the Minerva Research Group in the Biomedical Imaging Lab -
Department of Biomedical Engineering Faculty Publications [66]
Papers, Pre/Post-Prints, and Presentations by Faculty in the Department of Biomedical Engineering -
Department of Biomedical Engineering OSP Research Reports [20]
Office of Sponsored Programs research reports by faculty and researchers in the Department of Biomedical Engineering -
Department of Biomedical Engineering Theses and Dissertations [432]
Original work by students in the Department of Biomedical Engineering -
Department of Biomedical Engineering Undergraduate Research Option Theses [111]
Research Thesis Option for Biomedical Engineering Majors
Recent Submissions
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NANOPARTICLE-MEDIATED FUNCTIONAL AND MOLECULAR PHOTOACOUSTIC IMAGING FOR ASSESSMENT OF METASTATIC LYMPH NODES
(Georgia Institute of Technology, 2018-11-14)Despite advances in prevention, detection, and treatment of cancer, this disease remains the second leading cause of death in the United States. The majority of cancer related deaths are due to metastasis rather than primary ... -
Temporal cathepsin and matrix metalloproteinase activity in tendon extracellular matrix damage
(Georgia Institute of Technology, 2018-08-24)Tendinopathy, or tendon overuse, is one of the most common musculoskeletal disorders affecting athletes, laborers, and aging adults. If left untreated, overuse injury can progress to partial or full-thickness tears that ... -
ENGINEERING AN IMPROVED CARTILAGE REPAIR STRATEGY COMBINING CELLS AND ECM-DERIVED MATERIALS
(Georgia Institute of Technology, 2017-11-13)Osteoarthritis (OA) is the leading cause of disability in the US. The avascularity, low cellularity, and slow proliferation of chondrocytes as well as joint inflammation all limit the regenerative capacity of cartilage. ... -
MICROFLUIDIC DEVICES FOR STIFFNESS DEPENDENT ENRICHMENT OF RED BLOOD CELL SUBPOPULATIONS
(Georgia Institute of Technology, 2017-11-07)Microfluidic devices were designed, fabricated and tested for enriching red blood cell subpopulations based on their stiffness. First, stiffness dependent margination of red blood cells in high aspect ratio straight ... -
In Vivo and In Vitro Evaluation of an ECM-Based OA Therapy
(Georgia Institute of Technology, 2017-11-22)Osteoarthritis (OA) is a disease estimated to affect 10-12% of the adult US population and there are currently no clinically proven disease modifying therapies. Micronized dehydrated human amnion/chorion membrane (μ-dHACM) ... -
Investigating differential electrotaxis of glioblastoma and medulloblastoma spheroidal aggregates
(Georgia Institute of Technology, 2017-11-02)Treatment of brain and nervous system cancers remains a daunting clinical challenge, with one of the most common brain malignancies, glioblastoma, incurring a mere 5% five-year survival rate. In the search for new therapeutic ... -
Walk-away automation of in-vitro patch-clamp electrophysiology
(Georgia Institute of Technology, 2017-10-17)The complexity of the brain makes it a difficult target for systematized study. This is evidenced by the fact that to date, no unified taxonomy of cell type or connectivity pattern has emerged in the field of neuroscience. ... -
MIR-744 MODULATION BY DISTURBED FLOW AND its ROLE IN ENDOTHELIAL INFLAMMATION AND ATHEROSCLEROSIS
(Georgia Institute of Technology, 2017-11-13)Atherosclerosis is the leading cause of death in developed nations as it is the underlying cause of many cardiovascular diseases (CVD) such as myocardial infarction, ischemic stroke, and peripheral arterial disease. ... -
Spatiotemporal modeling of brain dynamics using machine learning approaches
(Georgia Institute of Technology, 2017-10-13)Resting state fMRI (rfMRI) has been widely used to study functional connectivity of human brains. Although most of the analysis methods to date have assumed the resting state to be stationary, this assumption is invalid ... -
Development of a Novel In Vitro Blood Brain Barrier Model for the Evaluation of Nanomedicines
(Georgia Institute of Technology, 2017-08-28)In this work, we present a novel microfluidic lumen system of the BBB (MLS-BBB) for the evaluation of multifunctional nanomedicines engineered for the treatment of medulloblastoma. Our MLS-BBB is designed to co-culture ... -
The mechanobiology of the T-Cell Receptor: Structurally connecting catch bonds with ligand binding and triggering
(Georgia Institute of Technology, 2017-08-28)The mechanism of the recognition of antigens and the activation of CD3 signaling domains by the T-Cell Receptor (TCR) are studied. The first part is focused to investigate how the information encoded in the peptide is ... -
DEVELOPMENT OF MICRONEEDLE PATCHES FOR MEASLES-RUBELLA VACCINATION AND EXTENDED DELIVERY VACCINATION
(Georgia Institute of Technology, 2017-11-14)Despite cheap and effective vaccines, nearly 1.5 million children die each year from vaccine preventable diseases. The World Health Organization has called for novel vaccine technologies that can reduce needle-and-syringe ... -
Effects of Cathepsin Proteolytic Network Dynamics on Extracellular Matrix Degradation in Biological Machines and Invasive Disease
(Georgia Institute of Technology, 2017-08-14)Proteases are enzymes that degrade proteins and play a major role in cellular homeostasis. When proteins are aged, defective, or just extracellular proteins taken up by the cell, these proteins are degraded by enzymes in ... -
Quantitative Detection and Delineation of Head and Neck Cancer Using Hyperspectral Imaging and Machine Learning
(Georgia Institute of Technology, 2016-11-02)Over 500,000 patients are diagnosed with head and neck squamous cell carcinoma worldwide each year. Most people who develop head and neck cancer have advanced disease at the time of diagnosis. Early cancer detection and ... -
Investigation of immunomodulation on myofibroblast activation: Implications for fibrotic development in wound healing
(Georgia Institute of Technology, 2017-05-03)Endogenous mechanisms of wound healing and remodeling are a particularly attractive avenue for targeting traumatic injury and incomplete growth. Macrophages are highly involved in this process, and generally exhibit either ... -
MRI-Based Investigation into the Effects of Simulated Microgravity on Cerebrospinal Fluid and Vascular Flow
National Aeronautics and Space Administration (NASA) astronauts have reported decrease in visual acuity due to Microgravity Ocular Syndrome (MOS) after returning from long duration space missions. It is hypothesized that ... -
Towards Passive Unlabeled Cell Sorting in a Microfluidic Flow Chamber
Cell separation is utilized for a variety of purposes in biomedicine, including clinical diagnosis, or batch purification or rare cell isolation within a research laboratory setting. The currently used methods for cell ... -
Mechanically Activated Currents in Mechanosensitive Cells
The purpose of this study is to analyze the effect of ultrasonic pressure on the mechanosensitive channel activity in the N2A cell line. Prior research has indicated that certain ion channels in the cellular membrane of ... -
Inflammatory CD8+ T Cells Are Reduced by Applying FTY-720 to Activate Sphingosine-1-Phosphate Receptor Signaling
Biomaterials generally induce a natural inflammatory response which can be altered by adding molecules to influence immune cell recruitment. Sphingosine-1-phosphatase (S1P) is a biological signaling lipid which performs ... -
Development of an EPIC-μCT imaging method for analyzing proteoglycan content in neocartilage constructs for the use in osteoarthritis therapeutics
Osteoarthritis (OA), characterized by debilitating joint pain, is a degenerative disease caused by the breakdown of cartilage in joints and adjacent bone. It is the most common type of arthritis, affecting 10-12% of the ...
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