Now showing items 558-577 of 798

    • P-Selectin Glycoprotein Ligand-1 Forms Dimeric Interactions with E-Selectin but Monomeric Interactions with L-Selectin on Cell Surfaces 

      Zhang, Yan; Jiang, Ning; Zarnitsyna, Veronika I.; Klopocki, Arkadiusz G.; McEver, Rodger P.; Zhu, Cheng (Georgia Institute of TechnologyPublic Library of Science, 2013-02-25)
      Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury. P-selectin dimerizes on the ...
    • Parameter estimation and network identification in metabolic pathway systems 

      Chou, I-Chun (Georgia Institute of Technology, 2008-08-25)
      Cells are able to function and survive due to a delicate orchestration of the expression of genes and their downstream products at the genetic, transcriptomic, proteomic, and metabolic levels. Since metabolites are ultimately ...
    • Parameter estimation in biochemical systems models with alternating regression 

      Chou, I-Chun; Martens, Harald; Voit, Eberhard O. (Georgia Institute of TechnologyBioMed Central, 2006-07-19)
      Background: The estimation of parameter values continues to be the bottleneck of the computational analysis of biological systems. It is therefore necessary to develop improved methods that are effective, fast, and ...
    • Parameter optimization in S-system models 

      Vilela, Marco; Chou, I-Chun; Vinga, Susana; Vasconcelos, Ana Tereza R.; Voit, Eberhard O.; Almeida, Jonas S. (Georgia Institute of TechnologyBioMed Central, 2008-04)
      Background: The inverse problem of identifying the topology of biological networks from their time series responses is a cornerstone challenge in systems biology. We tackle this challenge here through the parameterization ...
    • Particle Filtering for Geometric Active Contours with Application to Tracking Moving and Deforming Objects 

      Rathi, Yogesh; Vaswani, Namrata; Tannenbaum, Allen R.; Yezzi, Anthony (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 2005-06)
      Geometric active contours are formulated in a manner which is parametrization independent. As such, they are amenable to representation as the zero level set of the graph of a higher dimensional function. This representation ...
    • Particle Filtering for Registration of 2D and 3D Point Sets with Stochastic Dynamics 

      Sandhu, Romeil; Dambreville, Samuel; Tannenbaum, Allen R. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 2008-06)
      In this paper, we propose a particle filtering approach for the problem of registering two point sets that differ by a rigid body transformation. Typically, registration algorithms compute the transformation parameters by ...
    • Particle Filtering with Dynamic Shape Priors 

      Rathi, Yogesh; Dambreville, Samuel; Tannenbaum, Allen R. (Georgia Institute of TechnologySpringer Verlag, 2006-09)
      Tracking deforming objects involves estimating the global motion of the object and its local deformations as functions of time. Tracking algorithms using Kalman filters or particle filters have been proposed for tracking ...
    • Particle Filters for Infinite (or Large) Dimensional State Spaces- Part 1 

      Vaswani, Namrata; Yezzi, Anthony; Rathi, Yogesh; Tannenbaum, Allen R. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 2006-05)
      We propose particle filtering algorithms for tracking on infinite (or large) dimensional state spaces. We consider the general case where state space may not be a vector space, we assume it to be a separable metric space ...
    • Patient-specific finite element modeling of biomechanical interaction in transcatheter aortic valve implantation 

      Wang, Qian (Georgia Institute of Technology, 2015-01-02)
      Transcatheter aortic valve implantation (TAVI) is an effective alternative treatment option for patients with severe aortic stenosis, who are at a high risk for conventional surgical aortic valve replacement or considered ...
    • Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells 

      Nitin, Nitin; Santangelo, Philip J.; Kim, Gloria; Nie, Shuming; Bao, Gang (Georgia Institute of TechnologyOxford University Press, 2004)
      Real‐time visualization of specific endogenous mRNA expression in vivo has the potential to revolutionize medical diagnosis, drug discovery, developmental and molecular biology. However, conventional liposome‐ or dendrimer‐based ...
    • Perceiving Clutter and Surfaces for Object Placement in Indoor Environments 

      Schuster, Martin J.; Okerman, Jason; Nguyen, Hai; Rehg, James M.; Kemp, Charles C. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 2010-12)
      Handheld manipulable objects can often be found on flat surfaces within human environments. Researchers have previously demonstrated that perceptually segmenting a flat surface from the objects resting on it can enable ...
    • Performance comparison of support vector machine and relevance vector machine classifiers for functional MRI data 

      Perez, Daniel Antonio (Georgia Institute of Technology, 2010-07-12)
      Multivariate pattern analysis (MVPA) of fMRI data has been growing in popularity due to its sensitivity to networks of brain activation. It is performed in a predictive modeling framework which is natural for implementing ...
    • Phase transitions, curve evolution, and the control of semiconductor manufacturing processes 

      Berg, Jordan M.; Yezzi, Anthony; Tannenbaum, Allen R. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 1996-12)
      This paper presents a strategy for the estimation and control of certain semiconductor manufacturing processes, employing models developed to describe the dynamics of material interfaces in phase transition problems. ...
    • Plaque erosion and murine plaque stability: a biomechanical examination of exceptions to the phenomenon of plaque rupture 

      Campbell, Ian Christopher (Georgia Institute of Technology, 2013-01-04)
      Atherosclerotic plaque disruption leading to thrombosis has traditionally been studied as a rupture of a thin fibrous cap over a lipid-laden necrotic core. However, two noteworthy categories of plaques that do not rupture ...
    • Platelet Adhesion and Mechanosensing on Collagen Coated Substrates 

      Kee, Matthew (Georgia Institute of Technology, 2015-08-18)
      Platelets play a critical role in maintaining homeostasis of the body. In order to protect the body from significant injury, platelets adhere to the vascular wall preventing critical vascular system failure. When the ...
    • Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF 

      Yago, Tadayuki; Lou, Jizhong; Wu, Tao; Yang, Jun; Miner, Jonathan J.; Coburn, Leslie; López, José A.; Cruz, Miguel A.; Dong, Jing-Fei; McIntire,Larry V.; McEver, Rodger P.; Zhu, Cheng (Georgia Institute of TechnologyAmerican Society for Clinical Investigation, 2008-09)
      Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow ...
    • Point Set Registration via Particle Filtering and Stochastic Dynamics 

      Sandhu, Romeil; Dambreville, Samuel; Tannenbaum, Allen R. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 2009-07-16)
      In this paper, we propose a particle filtering approach for the problem of registering two point sets that differ by a rigid body transformation. Typically, registration algorithms compute the transformation parameters by ...
    • A Point-and-Click Interface for the Real World: Laser Designation of Objects for Mobile Manipulation 

      Kemp, Charles C.; Anderson, Cressel D.; Nguyen, Hai; Trevor, Alexander J. B.; Xu, Zhe (Georgia Institute of TechnologyAssociation for Computing Machinery (ACM), 2008-03)
      We present a novel interface for human-robot interaction that enables a human to intuitively and unambiguously se- lect a 3D location in the world and communicate it to a mo- bile robot. The human points at a location of ...
    • Polyketals: a new drug delivery platform for treating acute liver failure 

      Yang, Stephen Chen (Georgia Institute of Technology, 2008-10-22)
      Acute liver failure is a major cause of death in the world, and effective treatments are greatly needed. Liver macrophages (Kupffer cells) play a major role in the pathology of acute liver failure, and drug delivery ...
    • Polymer coatings to improve host response to implanted neural electrodes 

      Gutowski, Stacie Marie (Georgia Institute of Technology, 2014-06-18)
      Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement impairments including spinal cord injury and limb loss. Currently, chronically ...