Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
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Recent Submissions
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Convective intracellular macromolecule delivery for cell engineering applications
(Georgia Institute of Technology, 2020-04-25)Efficient intracellular delivery of target macromolecules remains a major obstacle in cell engineering, cell labeling, and other biomedical applications. Current standard methods of intracellular delivery, such as viral ... -
Perfluorocarbon Nanodroplets for Extravascular Imaging Applications
(Georgia Institute of Technology, 2020-04-23)Gas microbubbles are the contrast agent of choice for ultrasound imaging. These agents are excellent for highlighting vasculature; however, their micrometer-scale size prevents them from efficient trafficking within ... -
Engineering Nucleic Acid Nanostructures for Sensing and Control of Biomolecules and Their Environments
(Georgia Institute of Technology, 2020-05-05)Nucleic acid nanotechnology has emerged in the past decade as a powerful and versatile method to create functional and programmable nanostructures through molecular self-assembly. The research presented in this dissertation ... -
Development of Methodology to Estimate Fractional Flow Reserve Using Magnetic Resonance Imaging and Computational Fluid Dynamics
(Georgia Institute of Technology, 2020-04-09)Fractional flow reserve is the current gold standard for evaluating severity of coronary artery disease, but it is underutilized clinically due to its invasiveness. Recent efforts have worked toward developing non-invasive ... -
DNA Nanotechnology to Map and Manipulate Adhesion Forces at Fluid Interfaces
(Georgia Institute of Technology, 2020-03-27)Cells transmit piconewton (pN) receptor forces to ligands in the extracellular matrix (ECM) and on the surface of adjacent cells. These forces regulate functions ranging from adhesion to clotting and the immune response. ... -
Genome-scale modeling of redox metabolism and therapeutic response in radiation-resistant tumors
(Georgia Institute of Technology, 2020-03-25)Despite being one of the oldest forms of cancer therapy and still a primary treatment modality, radiation therapy is not effective across all cancer types and tumor resistance to radiation is still not well understood. As ... -
Genomic Analysis of Micro-inversions Based on High-Throughput Sequencing
(Georgia Institute of Technology, 2020-03-11)Genomic structural variations (SVs) are generally defined to include insertions, deletions, duplications, translocations, copy number variations and inversions. As with other types of variations, inversions are of great ... -
Ultrasound-guided transgene expression of KLK10 to inhibit atherosclerosis
(Georgia Institute of Technology, 2020-03-13)Atherosclerosis is the leading causes of death worldwide. Atherosclerotic plaques preferentially develop in regions exposed to disturbed flow. Vascular endothelial cells respond to blood flow through mechanosensors, which ... -
Elucidating the Neuroinflammatory Signaling Roles of Heme in Alzheimer's Disease Environments
(Georgia Institute of Technology, 2020-01-09)The prevalence of Alzheimer’s disease (AD) is rapidly increasing, yet there are currently no effective therapies to halt or slow disease progression. In light of the vast failures of therapies targeting traditional AD ... -
A FRAMEWORK FOR DESIGNING DATA-DRIVEN OPTIMIZATION SYSTEMS FOR NEURAL MODULATION: WITH APPLICATIONS IN OPTOGENETIC AND ELECTRICAL BRAIN STIMULATION
(Georgia Institute of Technology, 2021-04-30)Neural modulation has become a fundamental tool for understanding and treating neurological and psychiatric diseases and disorders including Parkinson’s disease and other movement disorders, epilepsy, depression, and a ... -
Evaluating the Effects of Particle-Delivered Combination Adjuvants on Antigen-Presenting Cells
(Georgia Institute of Technology, 2021-04-19)A current vaccine development challenge is to identify adjuvants with well-defined mechanisms of action that selectively induce antigen-presenting cell (APC) functions to modulate the immune response. APCs are activated ... -
UTILIZING HIGH-THROUGHPUT IN VIVO NANOPARTICLE SCREENS TO IMPROVE DRUG DELIVERY
(Georgia Institute of Technology, 2021-04-07)Nanoparticles improve drug efficacy by delivering drugs to sites of disease. To effectively deliver a drug in vivo, a nanoparticle must overcome physical and physiological hurdles that are not present in cell culture, yet ... -
Characterizing protein-protein and RNA-protein interactions in fixed cells and tissue
(Georgia Institute of Technology, 2019-10-28)The molecular machinery of the cell is governed by interactions between proteins, DNA, and RNA. For example, innate immune system activation is characterized by the formation and disassociation of protein complexes in a ... -
Enabling precision medicine by integrating multi-modal biomedical data
(Georgia Institute of Technology, 2020-12-15)With the advancement of technologies such as high-throughput sequencing, a massive amount of multi-modal biomedical data has been generated at an unprecedented speed and volume every year. However, extracting information ... -
Tunable Elastomeric Nano-Channels from Guided Fracture for Biopolymer Super Resolution Imaging
(Georgia Institute of Technology, 2019-11-06)This thesis describes the development of a polydimethylsiloxane (PDMS) based micro-, nano-fluidics system compatible with super-resolution imaging to capture and linearize extracted chromatin, for epigenetics studies. ... -
Anatomy of a Joint Sound – Using Joint Acoustic Emissions to Diagnose and Grade Musculoskeletal Disease and Injury
(Georgia Institute of Technology, 2019-11-12)There exists a need for a quantitative, objective measure of joint health status. In this work, a technique for recording the acoustic emissions (AEs) generated during joint flexion and extension was proposed. Analytical ... -
Quasi-periodic patterns of brain intrinsic activity coordinate the functional connections in humans
(Georgia Institute of Technology, 2019-11-12)The brain is a complex self-organizing biophysical system and intrinsically very active. How such intrinsic activity organizes the brain in humans is widely being studied during resting-state using functional magnetic ... -
Computational Modeling of Left Ventricle-Valve Dynamics using a Fluid-Structure Interaction Framework
(Georgia Institute of Technology, 2019-11-12)The left heart (LH) is a key player of the cardiovascular system. Diseases of and associated with the left ventricle (LV)-valve complex account for a large share of cardiovascular disease-related deaths. As accurate and ... -
Engineering cardiac biological pacemaker tissues to dissect source-sink mismatch in the heart
(Georgia Institute of Technology, 2019-10-01)Each and every heartbeat is initiated from, and driven by, the pacemaker cells in the sinoatrial node (SAN). More than 10 billion cardiac myocytes and non-myocytes make up the heart, but remarkably, it takes only a few ... -
Combining Sphingolipidomics and Computational Systems Biology to Study Red Blood Cell Sphingolipid Metabolism in Health and Disease
(Georgia Institute of Technology, 2019-08-27)Liquid chromatography-tandem mass spectrometry-based sphingolipidomics was combined with computational modeling to characterize sphingolipid metabolism in red blood cells and how it is altered in sickle cell disease. ...
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