Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
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Recent Submissions
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Nanoparticle-mediated functional and molecular photoacoustic imaging for assessment of metastatic lymph nodes
(Georgia Institute of Technology, 2018-11-14)Despite advances in prevention, detection, and treatment of cancer, this disease remains the second leading cause of death in the United States. The majority of cancer related deaths are due to metastasis rather than primary ... -
Temporal cathepsin and matrix metalloproteinase activity in tendon extracellular matrix damage
(Georgia Institute of Technology, 2018-08-24)Tendinopathy, or tendon overuse, is one of the most common musculoskeletal disorders affecting athletes, laborers, and aging adults. If left untreated, overuse injury can progress to partial or full-thickness tears that ... -
Engineering an improved cartilage repair strategy combining cells and ECM-derived materials
(Georgia Institute of Technology, 2017-11-13)Osteoarthritis (OA) is the leading cause of disability in the US. The avascularity, low cellularity, and slow proliferation of chondrocytes as well as joint inflammation all limit the regenerative capacity of cartilage. ... -
Microfluidic devices for stiffness dependent enrichment of red blood cell subpopulations
(Georgia Institute of Technology, 2017-11-07)Microfluidic devices were designed, fabricated and tested for enriching red blood cell subpopulations based on their stiffness. First, stiffness dependent margination of red blood cells in high aspect ratio straight ... -
In vivo and in vitro evaluation of an ECM-based OA therapy
(Georgia Institute of Technology, 2017-11-22)Osteoarthritis (OA) is a disease estimated to affect 10-12% of the adult US population and there are currently no clinically proven disease modifying therapies. Micronized dehydrated human amnion/chorion membrane (μ-dHACM) ... -
Investigating differential electrotaxis of glioblastoma and medulloblastoma spheroidal aggregates
(Georgia Institute of Technology, 2017-11-02)Treatment of brain and nervous system cancers remains a daunting clinical challenge, with one of the most common brain malignancies, glioblastoma, incurring a mere 5% five-year survival rate. In the search for new therapeutic ... -
Walk-away automation of in-vitro patch-clamp electrophysiology
(Georgia Institute of Technology, 2017-10-17)The complexity of the brain makes it a difficult target for systematized study. This is evidenced by the fact that to date, no unified taxonomy of cell type or connectivity pattern has emerged in the field of neuroscience. ... -
MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis
(Georgia Institute of Technology, 2017-11-13)Atherosclerosis is the leading cause of death in developed nations as it is the underlying cause of many cardiovascular diseases (CVD) such as myocardial infarction, ischemic stroke, and peripheral arterial disease. ... -
Spatiotemporal modeling of brain dynamics using machine learning approaches
(Georgia Institute of Technology, 2017-10-13)Resting state fMRI (rfMRI) has been widely used to study functional connectivity of human brains. Although most of the analysis methods to date have assumed the resting state to be stationary, this assumption is invalid ... -
Development of a novel In vitro blood brain barrier model for the evaluation of nanomedicines
(Georgia Institute of Technology, 2017-08-28)In this work, we present a novel microfluidic lumen system of the BBB (MLS-BBB) for the evaluation of multifunctional nanomedicines engineered for the treatment of medulloblastoma. Our MLS-BBB is designed to co-culture ... -
The mechanobiology of the T-Cell Receptor: Structurally connecting catch bonds with ligand binding and triggering
(Georgia Institute of Technology, 2017-08-28)The mechanism of the recognition of antigens and the activation of CD3 signaling domains by the T-Cell Receptor (TCR) are studied. The first part is focused to investigate how the information encoded in the peptide is ... -
Development of microneedle patches for measles-rubella vaccination and extended delivery vaccination
(Georgia Institute of Technology, 2017-11-14)Despite cheap and effective vaccines, nearly 1.5 million children die each year from vaccine preventable diseases. The World Health Organization has called for novel vaccine technologies that can reduce needle-and-syringe ... -
Effects of cathepsin proteolytic network dynamics on extracellular matrix degradation in biological machines and invasive disease
(Georgia Institute of Technology, 2017-08-14)Proteases are enzymes that degrade proteins and play a major role in cellular homeostasis. When proteins are aged, defective, or just extracellular proteins taken up by the cell, these proteins are degraded by enzymes in ... -
Quantitative detection and delineation of head and neck cancer using hyperspectral imaging and machine learning
(Georgia Institute of Technology, 2016-11-02)Over 500,000 patients are diagnosed with head and neck squamous cell carcinoma worldwide each year. Most people who develop head and neck cancer have advanced disease at the time of diagnosis. Early cancer detection and ... -
Rapid haptic perception using force and thermal sensing
(Georgia Institute of Technology, 2017-08-01)Tactile sensing can enable a robot to infer properties of its surroundings. Recent research has focused on robots that haptically perceive the world through exploratory behaviors that occur over tens of seconds. During ... -
Assistive mobile manipulation for users with severe motor impairments
(Georgia Institute of Technology, 2017-07-26)Mobile robots that can physically manipulate their environments have the potential to help persons with motor impairments perform a variety of tasks, including self-care tasks. Such assistive mobile manipulators (AMMs) ... -
The impact of TCR-CD3 and TCR-pMHC-CD8 interaction on T cell activation
(Georgia Institute of Technology, 2017-08-02)T cells play important roles in adaptive immunity through mediating clearance of bacteria, virus, and cancer cells. T cell receptor (TCR) recognizes antigen presented on the surface of antigen presenting cells (APC) in the ... -
Assessment of radiotherapy of cancer by apoptosis imaging with F-18 ML-10
(Georgia Institute of Technology, 2017-07-31)Cancer, currently the second leading cause of death in the United States, is expected to become the first killer in the near future by surpassing heart diseases. Molecular imaging has become a key tool in the biomedical ... -
Biosynthetic materials for pro-regenerative immune modulation
(Georgia Institute of Technology, 2017-06-20)Monocyte and macrophage recruitment underlies the host response to myriad tissue injuries and thus represents a powerful therapeutic target to potentially augment healing in numerous clinical indications with unmet need. ... -
Engineered materials for spatiotemporal regulation of monocyte and macrophage recruitment
(Georgia Institute of Technology, 2017-05-19)Significant advances have been made in the development of materials that better mimic native tissues through incorporation of biofunctionality, transplantation of exogenous cells, and recapitulation of host tissue mechanical ...
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