Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
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Recent Submissions
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Investigation of immunomodulation on myofibroblast activation: Implications for fibrotic development in wound healing
(Georgia Institute of Technology, 2017-05-03)Endogenous mechanisms of wound healing and remodeling are a particularly attractive avenue for targeting traumatic injury and incomplete growth. Macrophages are highly involved in this process, and generally exhibit either ... -
Rapid haptic perception using force and thermal sensing
(Georgia Institute of Technology, 2017-08-01)Tactile sensing can enable a robot to infer properties of its surroundings. Recent research has focused on robots that haptically perceive the world through exploratory behaviors that occur over tens of seconds. During ... -
Assistive mobile manipulation for users with severe motor impairments
(Georgia Institute of Technology, 2017-07-26)Mobile robots that can physically manipulate their environments have the potential to help persons with motor impairments perform a variety of tasks, including self-care tasks. Such assistive mobile manipulators (AMMs) ... -
The impact of TCR-CD3 and TCR-pMHC-CD8 interaction on T cell activation
(Georgia Institute of Technology, 2017-08-02)T cells play important roles in adaptive immunity through mediating clearance of bacteria, virus, and cancer cells. T cell receptor (TCR) recognizes antigen presented on the surface of antigen presenting cells (APC) in the ... -
Assessment of radiotherapy of cancer by apoptosis imaging with F-18 ML-10
(Georgia Institute of Technology, 2017-07-31)Cancer, currently the second leading cause of death in the United States, is expected to become the first killer in the near future by surpassing heart diseases. Molecular imaging has become a key tool in the biomedical ... -
Biosynthetic materials for pro-regenerative immune modulation
(Georgia Institute of Technology, 2017-06-20)Monocyte and macrophage recruitment underlies the host response to myriad tissue injuries and thus represents a powerful therapeutic target to potentially augment healing in numerous clinical indications with unmet need. ... -
Engineered materials for spatiotemporal regulation of monocyte and macrophage recruitment
(Georgia Institute of Technology, 2017-05-19)Significant advances have been made in the development of materials that better mimic native tissues through incorporation of biofunctionality, transplantation of exogenous cells, and recapitulation of host tissue mechanical ... -
OPTIMIZATION AND APPLICATION OF KILOHERTZ ELECTRICAL STIMULATION NERVE BLOCK TO AUTONOMIC NEURAL CIRCUITS
(Georgia Institute of Technology, 2017-05-15)Kilohertz Electrical Stimulation (KES) enables a rapid, reversible, and localized inhibition of peripheral nerve activity. Discovered in the early 1900’s, the utility and application of KES nerve block to treat symptoms ... -
Evaluation of targeting schemes for complement-modulating, strain-selective antimicrobial microparticles
(Georgia Institute of Technology, 2018-04-30)Here we present bifunctional microparticles that bind Escherichia coli (E. coli) bacteria via a cell membrane constituent while also activating the classical complement pathway. Carboxylated polystyrene microparticles 1 ... -
Mesenchymal stem cell therapies for the trabecular meshwork in glaucoma
(Georgia Institute of Technology, 2018-01-03)Glaucoma, a leading cause of blindness, affects over 70 million people worldwide, and its incidence is expected to continue to rise with an aging population. The exact origin for primary open angle glaucoma (POAG), the ... -
Mechanical properties of trabecular meshwork
(Georgia Institute of Technology, 2018-01-03)Glaucoma is the second leading cause of blindness. However, the precise mechanisms leading to vision loss in this disease remain unknown. Increased intraocular pressure (IOP) has been recognized as the most important risk ... -
Investigating the functional consequences of heterogeneity within immune cell populations
(Georgia Institute of Technology, 2017-06-14)A well-functioning immune system is the result of the combined efforts of a multitude of different cell types, performing separate but coordinated tasks. Diversity within these historically categorized “cell types” has ... -
Development of gold nanoparticle-based theranostic agents for molecular imaging and cancer therapy
(Georgia Institute of Technology, 2017-04-04)This research explored the use of Au nanoparticles on molecular imaging and cancer theranostics, with focuses on the fabrication of new materials, the incorporation of new medical isotope, as well as new labeling and ... -
A dynamic circuit mechanism for social bond formation in female prairie voles
(Georgia Institute of Technology, 2017-03-15)Adult pair bonding involves dramatic changes in the perception and valuation of another individual. One key change is that partners come to reliably activate the brain’s reward system, though the precise neural mechanisms ... -
Effects of quasi-periodic pattern regression on bold signals correlated with infraslow and higher frequency electrophysiology
(Georgia Institute of Technology, 2017-12-04)Functional MRI (fMRI) have provided information on networks, disorders, and cognitive performance of the brain. Recent studies have focused on fMRI during resting state (rs-fMRI) without any explicit tasks. To supplement ... -
The role of thalamic state in dynamic tactile encoding
(Georgia Institute of Technology, 2017-11-03)Sensory pathways extract information about the local environment to guide our actions and behaviors. The internal representation of the outside world is built on patterns of neural activity, commonly referred to as the ... -
Fabrication and characterization of multifunctional particles with spatially segregated proteins
(Georgia Institute of Technology, 2017-08-28)Multifunctional particles have been of great interest in a variety of fields including electronics, biology, chemistry, and medicine due to their ability to have multiple functionalities, both biological and non-biological, ... -
Targeted drug delivery for the treatment and diagnosis of cardiovascular disease
(Georgia Institute of Technology, 2017-08-28)Cardiovascular disease has accounted for more deaths than any other major cause of death in the United States every year since 1900, with the exception of 1918. Despite improvements in the management of cardiovascular ... -
A MICROFLUIDICS-BASED PARADIGM FOR CLINICAL LENTIVECTOR GENE TRANSFER
(Georgia Institute of Technology, 2016-11-15)Ex vivo gene therapy using lentiviral vectors (LVs) is a proven approach to treat and potentially cure many hematologic disorders and cancer, but remains stymied by cumbersome, cost-prohibitive, and scale-limited production ... -
CONDITIONING DENDRITIC CELL RESPONSES USING ENGINEERED BIOMATERIALS FOR IMMUNOTHERAPY
(Georgia Institute of Technology, 2016-11-15)Pivotal discoveries in the field of immunology over the last five decades have changed the way new therapies are designed for applications as varied as organ transplantation, autoimmune diseases or even cancer. In this ...
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