Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
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Recent Submissions
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Development of Multi-modality Polymer-coated Quantum Dots for Cancer Imaging
(Georgia Institute of Technology, 2016-06-14)Cancer has become a large threat to people’s health and lives in the world. It is very important if we can achieve the early diagnosis of cancer, which can significantly reduce cancer mortality and improve the life quality ... -
Rare-earth doped apatite nanocrystals for cell and implanted biomaterial tracking
(Georgia Institute of Technology, 2016-06-14)Apatite nanoparticles are the main inorganic component of human hard tissues, and have been used in repair of bone defects or scaffolds for bone tissue engineering. It has a stable hexagonal crystal structure, which could ... -
DELIVERY OF PROLYL HYDROXYLASE INHIBITORS TO MSC SPHEROIDS FOR ENHANCED ANGIOGENIC FACTOR SECRETION
(Georgia Institute of Technology, 2015-07-24)Mesenchymal stromal cells (MSCs) are of clinical interest due to their ability to differentiate towards musculoskeletal lineages, modulate inflammatory responses, and promote new blood vessel formation. Angiogenesis is an ... -
Magnetic Resonance Imaging of Intraspinal Stem Cell Grafts: Tracking and Targeted Transplantation
(Georgia Institute of Technology, 2015-07-22)Transplantation of cellular therapeutics into the spinal cord has been explored as treatment for a range of degenerative and traumatic diseases. The post-transplantation fate of cellular therapeutics is poorly understood ... -
Biomaterial strategies for improved bone healing with bone morphogenetic protein-2 delivery
(Georgia Institute of Technology, 2015-07-17)This thesis investigated hybrid biomaterial systems with controlled strategies for bone morphogenetic protein-2 (BMP-2) delivery to promote structural and functional restoration of segmental bone defects. Using a critically ... -
Modulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration
(Georgia Institute of Technology, 2015-07-17)Challenges to control delivered cell behavior, including viability and differentiation, remain a significant barrier to the translation of cell-based bone tissue engineering strategies. Our research objectives were to ... -
Development and optimization of near-infrared functional lymphatic imaging in health and lymphedema
(Georgia Institute of Technology, 2015-05-12)The lymphatic vasculature is present in nearly all tissues of the body and serves three primary functions: (1) regulation of tissue fluid homeostasis through the transport of large proteins and excess interstitial fluid, ... -
Hyperspectral endoscopy imaging: system development, clinical evaluation, and further application
(Georgia Institute of Technology, 2016-04-15)Hyperspectral (HS) imaging combines spectral measurement of a pixel with 2D imaging technology. It is capable to provide a series of images containing both spectral and spatial information, and has been widely used in ... -
Incorporation of bio-inspired microparticles within embryonnic stem cell aggregates for directed differentiation
(Georgia Institute of Technology, 2015-08-04)Embryonic stem cells (ESCs) are a unique cell population that can differentiate into all three embryonic germ layers (endoderm, mesoderm, and ectoderm), rendering them an invaluable cell source for studying the molecular ... -
Optogenetic dissection of septohippocampal neural circuitry for the treatment of epilepsy
(Georgia Institute of Technology, 2015-04-08)Over 50 million people worldwide suffer from epilepsy. Of these, nearly a third will be refractory to medical therapy, and many will be poor candidates for surgical resection. Thus there is a need for novel targets and ... -
Analyzing multicellular interactions: A hybrid computational and biological pattern recognition approach
(Georgia Institute of Technology, 2015-04-07)Pluripotent embryonic stem cells (ESCs) can differentiate into all somatic cell types, making them a useful platform for studying a variety of cellular phenomenon. Furthermore, ESCs can be induced to form aggregates called ... -
A toolkit for analysis of gene editing and off-target effects of engineered nucleases
(Georgia Institute of Technology, 2015-03-31)Several tools were developed to help researchers facilitate clinical translation of the use of engineered nucleases towards their disease gene of interest. Two major issues addressed were the inability to accurately predict ... -
Patient-specific finite element modeling of biomechanical interaction in transcatheter aortic valve implantation
(Georgia Institute of Technology, 2015-01-02)Transcatheter aortic valve implantation (TAVI) is an effective alternative treatment option for patients with severe aortic stenosis, who are at a high risk for conventional surgical aortic valve replacement or considered ... -
Proteolytically degradable microparticles for engineering the extracellular microenvironment of pluripotent stem cell aggregates
(Georgia Institute of Technology, 2014-12-12)During embryo development, extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) and promotes downstream cell specifications. Pluripotent stem cell (PSC) aggregates can recapitulate various aspects of ... -
Neural population coding of visual motion
(Georgia Institute of Technology, 2014-12-19)Motion in the outside world forms one of the primary uses of visual information for many animals. The ability to interpret motion quickly and accurately permits interaction with and response to events in the outside world. ... -
Treatment strategy for composite tissue limb trauma
(Georgia Institute of Technology, 2015-03-11)A majority of all fractures in current US armed conflicts are open fractures, in which a soft tissue injury is sustained along with the bone fracture. Even with gold standard treatment, in which muscle flaps are used to ... -
Investigation of mechanotransductory mechanisms in the pathogenesis of lung fibrosis
(Georgia Institute of Technology, 2014-04-07)Fibrosis of vital organs remains one of the leading causes of death in the developed world, where it occurs predominantly in soft tissues (liver, lung, kidney, heart) through fibroblast proliferation and deposition of ... -
Development of a coupled geometrical multiscale solver and application to single ventricle surgical planning
(Georgia Institute of Technology, 2015-01-09)Single ventricle heart defects are present in two of every 1000 live births in the US. In this condition the systemic and pulmonary blood flow mix in the functioning ventricle, resulting in insufficient blood oxygenation ... -
New toolsets to understand environmental sensation and variability in the aging process
(Georgia Institute of Technology, 2014-11-13)Aging is a complex process by which a combination of environmental, genetic and stochastic factors generate whole-system changes that modify organ and tissue function and alter physiological processes. Over the last few ... -
Shear stress, hemodynamics, and proteolytic mechanisms underlying large artery remodeling in sickle cell disease
(Georgia Institute of Technology, 2014-11-10)Sickle cell disease is a genetic disorder that affects 100,000 Americans and millions more worldwide. Although the sickle mutation affects one protein, which is only expressed in a single cell type, it has profound ...
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