Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
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Recent Submissions
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FRAMEWORK FOR A FIBRIN-SPECIFIC APTAMER FOR TARGETED DELIVERY OF FIBRINOLYTIC ESCHERICHIA COLI
(Georgia Institute of Technology, 2022-05-03)Blood clots cause roughly 100,000 deaths each year making it an important health concern. Blood clots form as fibrinogen is polymerized by the enzyme thrombin, forming a fibrin clot structure. Current anticoagulant and ... -
Microfluidic-based Tools to Investigate Gene Expression and Regulation with Tissue-specificity during Aging in Caenorhabditis elegans
(Georgia Institute of Technology, 2022-05-03)Aging is a complex, universal process that impacts us all differently. An increasingly important aspect of aging research is studying gene expression and regulation. Gene expression is age-, tissue-, and individual-dependent ... -
Design and Analysis of a Compact Mechanism for the Motion of Tendon-Driven Steerable Robotic Guidewires
(Georgia Institute of Technology, 2022-01-11)This thesis presents a novel compact guidewire advancement mechanism for micro- scale tendon-driven steerable robotic guidewires. Robotic guidewires allow surgeons to possess greater dexterity in minimally invasive surgeries ... -
Engineered biomaterials for drug delivery and therapeutic modulation in lymphatic tissues
(Georgia Institute of Technology, 2021-04-27)The lymphatic system plays a critical role in both fluid balance and the immune response, and its dysfunction is implicated in a wide variety of pathologies including cardiac disease, cancer, and lymphedema. While this ... -
Investigating the Brain States Behind FMRI Temporal Dynamics Using Frame-based Analysis Methods and Variational Autoencoders
(Georgia Institute of Technology, 2021-04-07)Functional MRI (fMRI) plays an important role in studying the brain functionality. In the past decade various resting state fMRI analysis methods have been proposed to study the dynamics in the functional connectivity of ... -
Temporal Regulation of Pro-Inflammatory Macrophage and Microglia Activation Dynamics Using Model Predictive Control
(Georgia Institute of Technology, 2021-01-22)Today, chronic inflammatory diseases, including neurodegenerative conditions, cancer, and heart disease, account for more than 50% of deaths globally. There is thus an urgent need for novel strategies to treat such diseases. ... -
Development and Characterization of Porcine Models of Glioma
(Georgia Institute of Technology, 2021-04-22)Development and Characterization of Porcine Models of glioma Muhibullah S. Tora 132 pages The development of porcine models of glioma using lentiviral vector mediated gene transfer was proposed. Lentiviral vectors were ... -
Modeling Humans at Rest with Applications to Robot Assistance
(Georgia Institute of Technology, 2021-12-10)Humans spend a large part of their lives resting. Machine perception of this class of body poses would be beneficial to numerous applications, but it is complicated by line-of-sight occlusion from bedding. Pressure sensing ... -
DEVELOPMENT OF A 3D TRACTION FORCE MICROSCOPY PLATFORM USING PEG-4MAL HYDROGELS FOR THE STUDY OF 3D VINCULIN MECHANOTRANSDUCTION
(Georgia Institute of Technology, 2021-12-13)Cells interact with the extracellular matrix (ECM) via reciprocal biophysical and biochemical signaling in a process known as mechanotransduction. Mechanotransduction controls multiscale biological processes from cellular ... -
Immunomodulation Following Severe Musculoskeletal Trauma to Improve Functional Regeneration
(Georgia Institute of Technology, 2021-12-03)Severe musculoskeletal trauma is one of the most prevalent types of trauma in both combat-wounded and civilian patients. However, despite advances in trauma care, morbidity and complication rates remain high with greater ... -
Single Cell RNA-Sequencing of Cardiac Progenitor Cells Across Patient Age Populations
(Georgia Institute of Technology, 2021-12-08)Human c-kit+ cardiac progenitor cells (CPCs) have seen success in the treatment of heart failure and myocardial dysfunction. However, research has demonstrated the reparative capacity of CPCs appears to be linked to the ... -
Electrospun Nanofibrous Patches for the Delivery of Cardiac-Derived c-Kit+ Cells
(Georgia Institute of Technology, 2021-12-06)Congenital heart disease (CHD) affects 8 in 1000 live births and is the number one cause of birth defect-related deaths. Current treatment is surgical correction of the abnormality, but these surgeries are often only ... -
Biomechanical Assessment of Tricuspid Regurgitation Using Experimental and Computational Approaches
(Georgia Institute of Technology, 2020-12-07)Functional Tricuspid Regugitation (FTR) accounts for over 80% of all incidences of tricuspid regurgitation (TR) and affects over 1.6 million Americans. The current gold standard treatment approach is implantation of an ... -
UNDERSTANDING WHOLE BRAIN ACTIVITY THROUGH BRAIN NETWORK MODELS
(Georgia Institute of Technology, 2020-12-07)The central nervous system coordinates many neural subpopulations connected via macroscale white matter architecture and surface cortical connections to produce complex behavior depending on environmental cues. The activity ... -
Prorgammable Immune Cytometry and Diagnostics
(Georgia Institute of Technology, 2020-11-30)Increasing our ability to broadly monitor T cell responses and sense disease biomarkers at depth throughout the course of a disease has provided clinicians with valuable new insights. For example, technologies that enable ... -
STRUCTURAL, MECHANICAL AND BIOLOGICAL ALTERATIONS TO THE LEFT VENTRICLE IN CHRONIC MITRAL REGURGITATION
(Georgia Institute of Technology, 2020-11-11)Heart failure (HF) is often the result of a direct stressor such as myocardial ischemia that injures the myocardium, or an indirect stressor such as valvular heart disease that alters the hemodynamic state in the heart and ... -
Development of microRNA triggered therapeutic oligonucleotides and gold nanoparticle conjugates to improve specificity of RNA therapeutics
(Georgia Institute of Technology, 2020-12-07)RNA-targeting oligonucleotide therapeutics and their nanoparticle conjugates hold great promise in treating intractable diseases, but their clinical applications are still limited by significant barriers including the lack ... -
BIOPRINTED CARDIAC PATCH COMPOSED OF CARDIAC PROGENITOR CELLS AND EXTRACELLULAR MATRIX FOR HEART REPAIR AND REGENERATION
(Georgia Institute of Technology, 2020-08-24)Congenital heart defects are present in 8 of 1000 newborns, and palliative surgical therapy has increased survival rates. Despite improved outcomes, many children develop reduced cardiac function and go on to heart failure ... -
Remote control of CAR T cell therapies by thermal targeting
(Georgia Institute of Technology, 2020-07-09)In 2017, the FDA approved two T cell therapies – Kymriah and Yescarta – for multiple relapsed or refractory hematological malignancies. In addition to providing new treatment options for patients with few viable alternatives, ... -
Variation of 3D Camera Based Anthropometry for Prediction of Cephalopelvic Disproportion in Ethiopia
(Georgia Institute of Technology, 2021-08-02)Cephalopelvic disproportion (CPD) is a dangerous pregnancy complication that often leads to maternal and perinatal morbidity or mortality if a cesarean section is not performed. Although for most people in the United States, ...
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