Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
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Recent Submissions
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Characterizing protein-protein and RNA-protein interactions in fixed cells and tissue
(Georgia Institute of Technology, 2019-10-28)The molecular machinery of the cell is governed by interactions between proteins, DNA, and RNA. For example, innate immune system activation is characterized by the formation and disassociation of protein complexes in a ... -
Enabling precision medicine by integrating multi-modal biomedical data
(Georgia Institute of Technology, 2020-12-15)With the advancement of technologies such as high-throughput sequencing, a massive amount of multi-modal biomedical data has been generated at an unprecedented speed and volume every year. However, extracting information ... -
Tunable Elastomeric Nano-Channels from Guided Fracture for Biopolymer Super Resolution Imaging
(Georgia Institute of Technology, 2019-11-06)This thesis describes the development of a polydimethylsiloxane (PDMS) based micro-, nano-fluidics system compatible with super-resolution imaging to capture and linearize extracted chromatin, for epigenetics studies. ... -
Anatomy of a Joint Sound – Using Joint Acoustic Emissions to Diagnose and Grade Musculoskeletal Disease and Injury
(Georgia Institute of Technology, 2019-11-12)There exists a need for a quantitative, objective measure of joint health status. In this work, a technique for recording the acoustic emissions (AEs) generated during joint flexion and extension was proposed. Analytical ... -
Quasi-periodic patterns of brain intrinsic activity coordinate the functional connections in humans
(Georgia Institute of Technology, 2019-11-12)The brain is a complex self-organizing biophysical system and intrinsically very active. How such intrinsic activity organizes the brain in humans is widely being studied during resting-state using functional magnetic ... -
Computational Modeling of Left Ventricle-Valve Dynamics using a Fluid-Structure Interaction Framework
(Georgia Institute of Technology, 2019-11-12)The left heart (LH) is a key player of the cardiovascular system. Diseases of and associated with the left ventricle (LV)-valve complex account for a large share of cardiovascular disease-related deaths. As accurate and ... -
Engineering cardiac biological pacemaker tissues to dissect source-sink mismatch in the heart
(Georgia Institute of Technology, 2019-10-01)Each and every heartbeat is initiated from, and driven by, the pacemaker cells in the sinoatrial node (SAN). More than 10 billion cardiac myocytes and non-myocytes make up the heart, but remarkably, it takes only a few ... -
Combining Sphingolipidomics and Computational Systems Biology to Study Red Blood Cell Sphingolipid Metabolism in Health and Disease
(Georgia Institute of Technology, 2019-08-27)Liquid chromatography-tandem mass spectrometry-based sphingolipidomics was combined with computational modeling to characterize sphingolipid metabolism in red blood cells and how it is altered in sickle cell disease. ... -
Engineering an aortic valve with cellular and mechanical functionality
(Georgia Institute of Technology, 2019-08-27)Heart valve disease is an increasing clinical burden associated with high morbidity and mortality. Current, valve replacements have a number of risks, such as thrombogenicity and calcification. For pediatric patients, a ... -
Aqueous Two-Phase System Micro-Assays Augmented by Automated Image Analysis
(Georgia Institute of Technology, 2019-11-12)Aqueous two-phase systems (ATPS) are a quirk of thermodynamics, wherein two immiscible solutions separate into stable liquid phases, containing primarily water. Conveniently, some biomolecules partition favorably into one ... -
Closed loop optogenetic control and thalamic state
(Georgia Institute of Technology, 2020-07-21)Dating as far back as the eighteenth century with Luigi Galvani's seminal studies in bioelectricity, interfacing with the nervous system at fast timescales has proven invaluable for scientific investigation as well as ... -
Development of a controlled-release platform for investigation of proteases following rotator cuff tear
(Georgia Institute of Technology, 2020-07-08)Surgical reattachment of torn rotator cuff tendons has a high rate of re-tear (failure) and the procedure does not reverse joint tissue degeneration present at the time of surgery. Following rotator cuff tear, three different ... -
System development and clinical applications of the handheld PA/US dual mode imaging system
(Georgia Institute of Technology, 2020-07-08)As an emerging technology, photoacoustic (PA) imaging (PAI) has gained lots of progresses in the past two decades. By combing optical contrast with ultrasound detection, PAI can maintain high spatial resolution in deeper ... -
Cathepsin-mediated fibrin(ogen)olysis in engineered microvascular networks and chronic coagulation in sickle cell disease
(Georgia Institute of Technology, 2020-05-17)Cysteine cathepsins are powerful proteases involved in tissue destructive disease progression, including angiogenesis and pathogenic vascular remodeling. However, some of their functions and mechanisms in biological processes ... -
An investigation of parameters that influence non-hepatocyte RNA delivery in vivo
(Georgia Institute of Technology, 2020-05-17)Lipid nanoparticle (LNP)-mediated nucleic acid delivery can regulate the expression of any gene, making it a promising way to treat disease. However, clinically relevant delivery of RNA therapeutics to non-hepatocytes in ... -
Mechanistic insight into disease pathogenesis of hexanucleotide repeat expansion disorders
(Georgia Institute of Technology, 2019-07-30)In 2011, two highly related hexanucleotide repeat expansions (HRE) were discovered as the causes of two different diseases – an intronic G4C2 HRE in the C9ORF72 gene locus represents the most prevalent genetic cause of ... -
Design and development of synthetic nanoparticle antibodies to deplete selected target cells for cancer immunotherapy
(Georgia Institute of Technology, 2019-07-22)Monoclonal antibodies (mAbs) have shown great promise as immunotherapy of cancer in the past decades. They mediate the antibody-dependent immune responses to eliminate the malignant or suppressive cells and proteins and ... -
Engineering a multi-functional DNA origami nanorod for the control of nanoscale processes
(Georgia Institute of Technology, 2019-07-19)Processes that occur at the nanoscale are the foundational building blocks of our world. As such, there is considerable interest in ways to study and manipulate matter at this scale, with applications in biomedicine and ... -
IMPROVING THE THERAPEUTIC FUNCTIONALITY OF NEURAL PROGENITOR CELLS BY ENCAPSULATION WITH CHONDROITIN-4-SULFATE-A HYDROGEL
(Georgia Institute of Technology, 2019-07-30)Stroke is a growing cause of morbidity and a significant cause of mortality in the United States. Currently, no therapies can promote recovery of neuronal networks lost to cerebral infarction. Tissue engineering strategies ... -
Multiplexed molecular imaging in the second near infrared window
(Georgia Institute of Technology, 2019-07-15)The implement and multiplexing of the second near-infrared window (NIR-II) imaging was demonstrated. Multiplexing is a novel idea in medical imaging, which describes the paradigm of integrating various diagnostic and ...
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