Department of Biomedical Engineering Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the Department of Biomedical Engineering.
All materials in SMARTech are protected under U.S. Copyright Law and all rights are reserved. Such materials may be used, quoted or reproduced for educational purposes only with prior permission, provided proper attribution is given. Any redistribution, reproduction or use of the materials, in whole or in part, is prohibited without prior permission of the author.
Recent Submissions
-
Deep-Ultraviolet Microscopy and Spectroscopy of Biological Samples
(Georgia Institute of Technology, 2022-01-10)Ultraviolet (UV) spectroscopy is a powerful and well-established tool for quantitative chemical and molecular analysis, however its application to biomedical molecular imaging and microscopy has been limited. Nevertheless, ... -
Magnetic Nanoparticle Targeting of a 3D Bioprinted Model of Pulmonary Vasculature to Address Restenosis
(Georgia Institute of Technology, 2022-12-02)Pulmonary Vein Stenosis (PVS) is a cardiovascular condition characterized by progressive lumen size reduction in one or more of the pulmonary veins. Central characteristics associated with pathological PVS state include ... -
Shifting the Balance of Inflammatory and Pro-Resolving Lipid Mediators in Volumetric Muscle Loss Injuries
(Georgia Institute of Technology, 2022-11-07)Extremity trauma involving large tissue loss (e.g., VML) presents a significant clinical challenge for both general and military populations. The frank loss of musculature characteristic of VML sufficiently disrupts or ... -
The Timescales of Transformation Across Brain Structures in the Thalamocortical Circuit
(Georgia Institute of Technology, 2022-11-09)Sensory processing requires reliable transmission of sensory information across multiple brain regions, from peripheral sensors, through sub-cortical structures, to sensory cortex, ultimately producing the sensory ... -
An Investigation of Scleral Biomechanics and Myopia in the Mouse
(Georgia Institute of Technology, 2022-12-19)The prevalence of myopia, or ”nearsightedness” is on the rise globally, set to affect about half of the global population by 2050. A myopic eye is characterized by a mismatch between the focal point of incoming light and ... -
Modelling and Characterization of Force Plate Measurements on Subacute Post-Concussion Subjects Through Machine Learning
(Georgia Institute of Technology, 2021-12-14)Mild traumatic brain injuries (mTBI) are one of the leading causes of neurological disorders. Symptoms after a mTBI may include headache, dizziness, and balance issues, among others, with vestibular disorders observed in ... -
High-throughput Tools and Techniques to Investigate Environmental Effects on Aging Behaviors in Caenorhabditis elegans
(Georgia Institute of Technology, 2021-12-09)Aging is modulated by genetic and environmental cues; however, it is difficult to study how these perturbations modulate the aging process in a robust, high-throughput manner. Methods to gather large-scale behavioral data ... -
Methods For High Throughput Single Cell Analysis Throughout Intact Human Brain Organoids
(Georgia Institute of Technology, 2021-12-09)Human brain organoids, three-dimensional spheres of human induced pluripotent stem cells (hiPSCs), have become widely used as a model system to study human neurodevelopment in recent years. Specifically, the model of intact ... -
Particle Image Velocimetry in Cerebral Aneurysm Models to Evaluate Fluid Dynamic Performance of Flow Diverting Stents Across Parent Vessel Sizes
(Georgia Institute of Technology, 2021-12-14)A cerebral aneurysm is a life-threatening abnormality that requires clinical intervention. Appropriate treatment is essential in order to avoid aneurysmal hemorrhage, which can result in irreparable damage or death. In ... -
Noninvasive vagus nerve stimulation for neuromotor adaptations
(Georgia Institute of Technology, 2021-12-13)Impaired motor function is often the result of neuromuscular disorders or advanced age. Neural adaptations associated with rehabilitative training are known to be correlated with the recovery and improvement of motor ... -
Relating Mechanical and Genetic Data at Single Cell Level across the Genome to Investigate Metastasis
(Georgia Institute of Technology, 2021-12-10)Nine out of every ten cancer-related deaths is caused by metastasis, but the molecular mechanisms driving this process are still not fully understood. Several studies have implicated that as a cell’s metastatic potential ... -
Optimizing T Cell Manufacturing and Quality Using Functionalized Degradable Microscaffolds
(Georgia Institute of Technology, 2021-09-24)Adoptive cell therapy using chimeric antigen receptor (CAR) T cells have shown promise in treating cancer, but manufacturing large numbers of high quality cells remains challenging. Currently approved T cell expansion ... -
Identification of cellular attributes that relate to the therapeutic efficacy of Mesenchymal Stromal Cells for treatment of Osteoarthritis
(Georgia Institute of Technology, 2021-08-24)Osteoarthritis (OA) is the most prevalent chronic disease of the joints and leads to degeneration of articular cartilage surfaces. While physical therapy and weight loss have demonstrated improved functionality in patients ... -
CD28 and TCR In-Situ Biophysical Analyses Inform T Cell Immunity Mechanisms
(Georgia Institute of Technology, 2021-11-01)This work investigates two receptors on T lymphocytes that shape immunity, the T cell receptor (TCR) and cluster of differentiation 28 (CD28). T cells coordinate adaptive immunity, but how signaling via TCR and CD28 ... -
Inverted Adipose Mammary Microtissues for Early-Stage Tumor Progression Testing
(Georgia Institute of Technology, 2020-12-10)Stromal adipocytes have been increasingly shown to play a role in multiple stages of breast cancer progression. While new culture models are being developed to test hypotheses about interplay between adipose tissue and ... -
Proof-of-Concept of a Jagged1-functionalized PEG-4MAL Hydrogel
(Georgia Institute of Technology, 2022-08-01)Craniofacial bone deformities can arise from injuries, congenital defects, cancer, or other causes, leaving patients with impairments and psychological stress. Reconstruction of bone through bone grafts or bone anabolic ... -
OSCILLATORY DYNAMICS IN ANTIDEPRESSANT DEEP BRAIN STIMULATION
(Georgia Institute of Technology, 2022-08-02)Deep brain stimulation (DBS) is a neurosurgical treatment being investigated for severe brain disorders including clinical depression. Our lab precisely targets and electrically stimulates specific white matter tracts ... -
Microneedle Patch Delivery of Controlled-Release Microspheres to the Skin
(Georgia Institute of Technology, 2022-07-07)Self-administration is desirable for drug delivery due to better patient compliance and fewer administration logistics compared to traditional injection, especially for long-term treatment. Microneedle (MN) patches present ... -
Purinergic Hydrogels for Cardiovascular Applications
(Georgia Institute of Technology, 2021-08-02)Despite great advances, ischemic cardiovascular disease is still the leading cause of morbidity and mortality, and novel interventions are needed to improve outcomes. The best current treatment for ischemia, rapid reperfusion ... -
ENGINEERED ACTIVITY SENSORS FOR PREDICTIVE IMMUNE MONITORING
(Georgia Institute of Technology, 2021-08-02)Immunotherapies are transforming the treatment of immunological disorders for patients with intractable diseases, for instance through the activation of anti-tumor immunity or the suppression of host reactivity against ...
RSS 1.0