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dc.contributor.advisorHu, David
dc.contributor.authorLamarca, Morgan
dc.date.accessioned2018-08-20T19:10:30Z
dc.date.available2018-08-20T19:10:30Z
dc.date.created2017-05
dc.date.submittedMay 2017
dc.identifier.urihttp://hdl.handle.net/1853/60330
dc.description.abstractThe kinematic processes of the small intestine play integral roles in overseeing the digestion and transportation of food throughout the gastrointestinal tract. Specifically responsible for governing the flow and digestion of chyme along the gastrointestinal tract are the two fundamental patterns of motility, propulsion and mixing [1]. While peristalsis is the principle muscle contraction for propulsive motility, segmentation contractions are responsible for mixing and chopping the chyme [2]. Previous studies on the contraction kinematics of the small intestine have provided evidence that contraction frequencies alter in response to different types of food. We propose that the pattern of segmental contraction varies in response to the different compositions of intraluminal contents as well. As the composition of chyme alters and it becomes less dense, segmental contraction frequency increases as a response. Our in vivo observational technique conducted on the small intestine of male Sprague-Dawley rats is much less invasive than previous studies, thus allowing us to better quantify the kinematic properties of the small intestine, such as frequency and amplitude of contraction. Understanding and comparing essential patterns of motility across patients can improve medical diagnostics as well as the manufacturing of food supplements and pharmaceutical medications.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectGastrointestinal motility
dc.subjectSegmentation contraction
dc.subjectSegmentation contraction frequency
dc.subjectSmall intestine
dc.subjectchyme density gradient
dc.subjectin vivo animal model
dc.titleGastrointestinal Motility: Kinematic Properties of Segmentation Contraction
dc.typeUndergraduate Research Option Thesis
dc.description.degreeUndergraduate
dc.contributor.departmentBiology
thesis.degree.levelUndergraduate
dc.contributor.committeeMemberGoodisman, Michael
dc.contributor.committeeMemberMendelson, Joseph
dc.date.updated2018-08-20T19:10:30Z


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