School of Chemistry and Biochemistry
The School of Chemistry and Biochemistry maintains research facilities in the Boggs Chemistry Building and the Institute for Bioengineering and Biosciences. To augment academic departments, a number of "centers" have been formed to nurture interdisciplinary research in a variety of areas, ranging from biotechnology to polymers, microelectronics and manufacturing.
Students, faculty and staff contribute to highly collaborative and interdisciplinary research programs.
All materials in SMARTech are protected under U.S. Copyright Law and all rights are reserved. Such materials may be used, quoted or reproduced for educational purposes only with prior permission, provided proper attribution is given. Any redistribution, reproduction or use of the materials, in whole or in part, is prohibited without prior permission of the author.
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School of Chemistry and Biochemistry OSP Research Reports [269]
OSP research reports by faculty and researchers in the School of Chemistry and Biochemistry -
School of Chemistry and Biochemistry Theses and Dissertations [1415]
Original work by students in the School of Chemistry and Biochemistry -
School of Chemistry and Biochemistry Undergraduate Research Option Theses [41]
Research Thesis Option for Chemistry and Biochemistry Majors
Recent Submissions
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Carrier protein and halogenase selectivity in the biosynthesis of halogenated pyrroles
Natural product biosynthetic pathways often share similar architecture even when they lead to different final products. In polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) enzymatic pathways, the ... -
Antibody targeted delivery of prodrug converting enzymes using protein nanoparticle platform for HER2-positive breast cancer therapy
Approximately 1 in 8 women in the United States will be diagnosed with breast cancer. Among these women, 25-30% will have breast cancer where the HER2 gene is overexpressed and human epidermal growth factor receptor 2 ... -
Towards More Efficient ab initio Computation of Physical Properties
The introduction of the modern computer has been a boon to myriad scientific communities. Scientific experiment can be categorized into the categories of physical experiment and thought experiment. In the chemical arena, ... -
Heme Trafficking Under Lead Stress in S. Cerevisiae
Heavy metals, including lead, are significant for their toxicity to the environment and to organisms’ physiology. Lead has been shown to induce oxidative stress in cells through mitochondrial perturbation, as well as ... -
Steps to Improving Stability of the β-propeller Structure of Myocilin's Olfactomedin Domain: Understanding the Evolution of the β-propeller
Olfactomedin (OLF) domain-containing proteins, first identified in relation to bullfrog olfactory chemoreception, are part of a superfamily of proteins implicated in many important biological functions and human diseases. ... -
CONTRIBUTIONS OF ACTIVE SITE RESIDUES TO SUBSTRATE BINDING AND CATALYSIS OF 5-NITROANTHRANILIC ACID AMINOHYDROLASE
(Georgia Institute of Technology, 2019-04-30)Synthetic and naturally occurring nitroaromatic compounds are recalcitrant to degradation and they are toxic/mutagenic. The symbiont Bradyrhizobium sp. JS329 is the first microbe found to degrade a biological nitroaromatic ... -
Testing the Boundaries of Novel Friedel-Crafts-type Methodologies Inspired by N-Heteroaromatic Medicinal Targets
(Georgia Institute of Technology, 2019-03-29)Methodology development is an essential pursuit to enable the synthesis of pharmaceutically-relevant targets. The emergent concept of privileged scaffolds has provided a framework for focused synthetic methodology development ... -
Laser-induced Acoustic Desorption Atmospheric Pressure Photoionization Mass Spectrometry for Complex Mixture Analysis
(Georgia Institute of Technology, 2019-03-14)The field of mass spectrometry has seen significant development with regards to ambient ionization techniques. However, many such techniques are limited by their desorption efficiency and typically are best suited to ionize ... -
LOW COORDINATE LATE TRANSITION METAL PLATFORMS FOR CO₂ AND CO COMPLEXES
(Georgia Institute of Technology, 2019-02-19)Transition metal complexes that enable catalytic reactions to selectively and efficiently yield different products remain as indispensable tools in the synthetic chemist’s toolbox. Ligands, through their electronic and/or ... -
GREEN FLUORESCENT PROTEIN INSPIRED CHROMOPHORE AS ESTROGEN RECEPTOR AGONIST-SYNTHESIS, BIOLOGICAL EVALUATIONS AND CELLULAR APPLICATION
(Georgia Institute of Technology, 2019-01-22)Nuclear receptors are ligand activated transcription factors that are widely distributed throughout the mammalians. There are 48 known human nuclear receptors within the body located in various systems. While some nuclear ... -
Excited State Design of Carbazole-Oxadiazole Compounds for Thermally Activated Delayed Fluorescence
(Georgia Institute of Technology, 2018-12-04)Materials containing 9H-carbazole and 2,5-diphenyoxadiazole functionalities have been widely exploited in organic electronic applications. Only very recently, however, have they been combined to obtain fluorophores exhibiting ... -
NEW CHEMICAL LINKAGE SYSTEMS TO ADDRESS BIOLOGICAL PROBLEMS
(Georgia Institute of Technology, 2018-04-10)The research reported in this thesis explored and developed the formation of reversible and irreversible chemical linkages for use in biological systems. Through the synthesis of a variety of peptides and small molecules, ... -
Deciphering protein glycosylation through novel mass spectrometry-based proteomic strategies
(Georgia Institute of Technology, 2018-04-10)Protein glycosylation is essential for cell survival and proliferation. Comprehensive analysis of protein glycosylation can aid in a better understanding of protein functions, cellular activities, and the molecular mechanisms ... -
Microbial Synthesis of Terpene and Fatty Acid Biofuel Precursors
(Georgia Institute of Technology, 2018-01-12)Our dependence on petroleum-derived fuels has accelerated the need for renewable fuel production. Microbial engineering is a promising avenue for production of advanced biofuels that can be dropped into existing transportation ... -
Trapping internal water clusters and hydrogen-bonding networks in photosynthetic oxygen evolution
(Georgia Institute of Technology, 2018-01-09)To summarize the work presented in this thesis, I have investigated the structure and function of the internal hydrogen-bonding network in PSII in three different ways. In the first (Chapter 2), I used an infrared signal ... -
Targeted delivery of histone deacetylase inhibitors for use in cancer therapy
(Georgia Institute of Technology, 2016-08-22)Cancer is one of the leading causes of death around the world, with lung, breast and prostate cancer being the most common cancers. Most of current cancer treatments are associated with various side effects such as depression, ... -
Black to transmissive electrochromatic windows
(Georgia Institute of Technology, 2012-12) -
Determination of the chemistry involved in enzymatic breakdown of crystalline cellulose
(Georgia Institute of Technology, 2010-08)Lignin, cellulose and hemicellulose, the key components of lignocellulosic biomass are closely associated with each other at the plant cell level. This close association, together with the partly crystalline nature of ... -
Optical and electronic processes in metal nanoparticle-conjugated organic materials
(Georgia Institute of Technology, 2010-08)Gold nanoparticles (ca. 3 nm in diameter) coated with bis(diarylamino)biphenyl-based thiols with two different alkyl spacers (propyl and dodecyl) between the chromophore and the surface-anchoring thiol group have been ... -
Rapid characterization of poor-quality medicines using mass spectrometry
(Georgia Institute of Technology, 2018-11-19)Communities worldwide, especially in the developing world, are afflicted with poor-quality medicines disguised as genuine medicines used for treatment of common infections. Poor-quality medicines range from expired genuine ...
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