School of Chemistry and Biochemistry Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the School of Chemistry and Biochemistry
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Recent Submissions
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The Ribosome: A Window in Time
(Georgia Institute of Technology, 2017-04-07)The ribosome, in analogy with a tree, contains a record of its history, spanning 4 billion years of life on earth. The information contained within ribosomes connects us to the prehistory of biology. Details of ribosomal ... -
Novel mass spectrometry-based methods to identify and quantify extracellular glycoproteins
(Georgia Institute of Technology, 2017-04-06)Extracellular glycoproteins are extremely important to a variety of biological processes, including immune response, cell interactions and disease development. Despite their critical importance, glycoproteins are challenging ... -
Exploiting the Oxidizing Capabilities of Laccases for Sustainable Chemistry
(Georgia Institute of Technology, 2017-04-05)Enzyme catalyzed processes are rapidly becoming a viable means to accomplish chemical transformations in the field of synthetic chemistry. In an era where concern about the current and future state of the environment is ... -
Towards the elucidation of the mechanism of the antibiotic activity of tamoxifen
(Georgia Institute of Technology, 2017-04-24)Antibiotic resistance is increasingly a health and financial burden on the global population. Use and misuse of antibiotics has led to increased frequencies of antibiotic-resistant infections worldwide, leading to fatalities ... -
Improved Sensitivity in Fluorescence Spectroscopy and Microscopy
(Georgia Institute of Technology, 2016-04-05)Fluorescence microscopy and spectroscopy have been successfully utilized in a range of biological applications. However, challenges still remain due to endogenous background signal that obscures measurements and spatial ... -
Progress Towards the Development of G-Protein Coupled Receptor Based Logic Gates
(Georgia Institute of Technology, 2016-05-03)The yeast Saccharomyces cerevisiae along with the bacterium Escherichia coli have been popular model organisms for the creation or modification of chemical producing or chemical sensing strains. Yeast has been used to ... -
3D naphthalene and perylene diimide derivatives as non-fullerene acceptors for organic solar cells
(Georgia Institute of Technology, 2016-12-13)Non-fullerene acceptor (NFA) have great potential to replace fullerene materials and overcome their limitations such as relatively weak light absorption, poor morphological stability, and synthetic complexity of introducing ... -
Creating a library of genetically encoded heme sensors with varying binding affinities
(Georgia Institute of Technology, 2016-12-09)Heme is an important biological metallo-cofactor that also works as a signaling molecule in cells. Despite its importance, heme trafficking and mobilization in the cell are currently not well understood, in part due to the ... -
Long range ordering in poly(3-hexylthiophene) fluids and films: Implications for organic electronics
(Georgia Institute of Technology, 2016-11-15)Understanding and controlling polymer semiconductor morphology is critical to achieving high charge carrier mobility and enabling widespread use of organic electronic devices such as organic photovoltaics, organic ... -
Spectroscopy of molecular ions in Coulomb crystals
(Georgia Institute of Technology, 2016-11-17)This thesis presents the results of my graduate work which has concentrated on applying laser-cooling techniques to molecular ions, specifically CaH⁺ and BH⁺ ions for the study of their rovibronic spectroscopy. The goal ... -
Cation effects on the folding of ribosomal RNA
(Georgia Institute of Technology, 2015-11-16)Folding of ribonucleic acids (RNAs), including those which constitute the functional components of the ribosome, invariably involves positively charged metal ions (cations). Here, we explore the intricate relationships ... -
Customized Conjugation: Tailored Π-Systems for Organic Electronic Applications
(Georgia Institute of Technology, 2015-10-29)The versatility of the conjugated π-system allows it to be structurally tailored and imbued with properties relevant for organic electronics. Judicious selection of synthons and synthetic methodologies enables the modular ... -
Toward a quantitative understanding of the shape-controlled synthesis of colloidal noble-metal nanocrystals
(Georgia Institute of Technology, 2015-10-29)This dissertation is focused on the development of a quantitative analysis of the thermodynamic and kinetic factors responsible for the mechanisms and pathways during the nucleation and growth of noble-metal nanocrystals. ... -
REDOX-ACTIVE CONJUGATED POLYMERS FOR ELECTROCHROMIC AND SUPERCAPACITIVE APPLICATIONS
(Georgia Institute of Technology, 2015-08-19)The study of conducting, redox-active polymers has rarely wanted for potential applications, ranging from modulation of optical properties, charge storage, drug release, and more. This subset of redox-active polymers stands ... -
Strained carbocycles as gateways to polycyclic molecular scaffolds and natural products targets
(Georgia Institute of Technology, 2016-08-01)Cyclopropanes and cyclobutanes, when activated with donor and acceptor groups, provide facile access to a plethora of interesting chemical scaffolds. Importantly, D-A cyclopropanes and cyclobutanes undergo efficient ... -
Polyaniline sorption of ruthenium
(Georgia Institute of Technology, 2016-07-26)The goal of this project was to determine if polyaniline would be an adequate matrix to sequester ruthenium from aqueous solutions. Ruthenium is a component of radioactive hazardous waste, and therefore developing a sorption ... -
Additives for active layer design & trap passivation in organic photovoltaics
(Georgia Institute of Technology, 2016-07-22)This dissertation explores the employment of solid additives in organic photovoltaic devices with the goal of customizing the electronic properties of the semiconducting materials, as well as the morphological effects of ... -
Molecular simulations of the bulk-heterojunction morphology in organic solar cells
(Georgia Institute of Technology, 2016-07-07)In this Thesis, we aim to elucidate clear connections between the chemical functionality and molecular morphologies of a number of high-performing or benchmark π-conjugated materials used in OSCs. We proceed to link these ... -
Controlled doping of organic semiconductors and 2d materials with molecular reductants and oxidants
(Georgia Institute of Technology, 2016-07-12)New air-stable dimeric n-dopants are synthesized and studied in detail with respect to the kinetics of both their redox reaction in solution with and their doping in the solid-state of various organic semiconductor acceptors. ... -
Novel platinum-based nanocrystals and their use as electrocatalysts for the oxygen reduction reaction
(Georgia Institute of Technology, 2016-07-21)Owing to the low operating temperature and high power density, polymer electrolyte membrane fuel cells (PEMFCs) are promising candidates to replace the conventional combustion engines in the automotive industry. The poor ...
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