School of Chemistry and Biochemistry Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the School of Chemistry and Biochemistry
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Recent Submissions
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Rapid characterization of poor-quality medicines using mass spectrometry
(Georgia Institute of Technology, 2018-11-19)Communities worldwide, especially in the developing world, are afflicted with poor-quality medicines disguised as genuine medicines used for treatment of common infections. Poor-quality medicines range from expired genuine ... -
Exploitation of plasmonic nanoparticles for optical enhancements in composite materials
(Georgia Institute of Technology, 2018-11-13)This dissertation explores the optical properties of plasmonic metal nanoparticles and their application in composite materials. Plasmonic metal nanoparticles can be used to concentrate and manipulate light. Due to the ... -
Structure-property relationships of nonlinear optical chromophores and their application towards sensing in biological systems
(Georgia Institute of Technology, 2018-11-15)This dissertation investigates the use of nonlinear optical chromophores, typically with strong second-order nonlinearities, for sensing applications in biological systems. The two main areas of focus, in terms of biological ... -
Prebiotic inspiration to functional application: Synthetic and mechanistic investigations of glyoxylate and its formal dimer dihydroxyfumaric acid
(Georgia Institute of Technology, 2018-11-09)The origins of life on earth has been a topic of study in the scientific community for many years. In recent decades, as an understanding of biochemistry developed, how the biomacromolecules that make up life were formed ... -
Novel phosphatriptycene and NHC supported late transition metal complexes for small molecule transformations
(Georgia Institute of Technology, 2018-11-09)This thesis focuses on the synthesis and characterization of late transition metal complexes supported by novel caged phosphine and NHC ligands, and the study of their reactivity in small molecule transformations. The first ... -
Data mining the structure of the ribosome to unravel the history of proteins
(Georgia Institute of Technology, 2018-11-09)Contained within every cell of every organism on Earth is a molecular fossil that has recorded the evolution of life since its origin approximately 4 billion years ago. Composed of both RNA and protein, the ribosome is the ... -
Computational study of point defects in metal-organic frameworks
(Georgia Institute of Technology, 2018-10-29)Metal-Organic Frameworks (MOFs) are a class of porous materials composed of metal clusters connecting by organic ligands and forming in one-, two-, or three- dimensional structures. The tunable pore sizes, ultrahigh surface ... -
Spectroscopic characterization of nonlinear optical and biophotonic materials
(Georgia Institute of Technology, 2018-10-29)In this dissertation, three studies were presented that involve the spectroscopic characterization of either nonlinear optical or biophotonic materials. The first study (Chapter 3) proposed judicious bulky substitution of ... -
Waves of communication: Metabolomics describe the nature and role of waterborne cues in the marine environment
(Georgia Institute of Technology, 2017-11-13)Waterborne cues are important tools for signaling in the marine environment. Despite decades of dedicated research, we know little about the chemical nature of these cues and of the physiological response by individuals ... -
Design of polymer architectures for catalysis
(Georgia Institute of Technology, 2017-11-13)Polymer structures provide tunable platforms for catalyst design due to the high degree of structural control possible in their synthesis. In this study, several different molecular catalysts have been prepared on polymer ... -
Preparation and characterization of carbon-supported polyaniline-palladium composite electrodes
(Georgia Institute of Technology, 2017-10-20)Polyaniline (PANI) is an electronically conducting polymer whose redox state can be precisely controlled. The nitrogen groups in the polymer are weak bases, which can be protonated and because of the redox and acid –base ... -
Simulations of multi-photon dissociation of calcium monohydride and calcium monodeuteride ions
(Georgia Institute of Technology, 2017-11-09)We observe various transitions in CaH$^+$ and CaD$^+$ by resonance enhanced multiphoton photodissociation spectroscopy in a Coulomb crystal. We report the the vibronic 1$^{1}\Sigma$ v$_{0}$ $\longrightarrow$ 2$^{1}\Sigma$ ... -
Modified monoterpene indole alkaloid production in the yeast Saccharomyces cerevisiae
(Georgia Institute of Technology, 2017-08-25)Alkaloids are a large group of plant natural products that have important therapeutic value. Because of their chemical complexity, therapeutic alkaloids are often obtained via plant-extraction. The microbial synthesis of ... -
Exploring fibronectin's integrin binding domain effects on lung fibroblast integrin specificity and downstream phenotypic differences
(Georgia Institute of Technology, 2017-08-28)Recombinant proteins which mimic fibronectin’s (Fn’s) integrin binding domain in conformationally stable and unfolded states are investigated to explore integrin specificity and downstream phenotypic differences on lung ... -
Effect of titanium dioxide nanoparticle on the redox regulatory network of cells
(Georgia Institute of Technology, 2015-04-27)The extensive industrial and commercial use of titanium dioxide nanoparticles (TiO2 NPs) in paints, cosmetics, and as food coloring additives is associated with high levels of TiO2 NPs released into the environment and ... -
Organic donor-acceptor chromophore-catalyst assembly for solar fuels
(Georgia Institute of Technology, 2015-01-12)In this thesis, a novel chromophore-catalyst molecular assembly is synthesized in the pursuit of affecting rapid water oxidation driven by light. The compound is inspired by previous work done in the lab of John R. Reynolds ... -
Characterization of DNA duplex structure, stability and formation kinetics in a eutectic solvent and its aqueous mixtures
(Georgia Institute of Technology, 2015-02-06)In this work, properties and behavior of DNA oligonucleotides in a non-aqueous eutectic comprised of glycerol and choline chloride mixed at varying ratios, as well as aqueous mixtures of the eutectic are explored. Physical ... -
Numerical methods for chemical analysis of complex surfaces
(Georgia Institute of Technology, 2018-07-25)Temperature programmed desorption (TPD) is a classic surface science experiment that provides information regarding gas adsorption thermodynamics and desorption kinetics. Conventional TPD data analysis methods are inadequate ... -
Novel (homo-)Nazarov approaches to complex polycycles and application to bioactive targets
(Georgia Institute of Technology, 2018-07-25)Complex carbocycles and heterocycles make up a large majority of natural product scaffolds and active pharmaceutical ingredient cores. As a result of this, developing methods to obtain such scaffolds in new, greener, and ... -
Materials for next-generation lithography: Crosslinked molecular resists and photo-patternable underlayers
(Georgia Institute of Technology, 2018-07-25)As feature sizes on integrated circuits (computer chips) continue to decrease in accordance with Moore’s Law, new technologies are needed to maintain pace. Next-generation lithographic techniques, including extreme ultraviolet ...
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