School of Chemistry and Biochemistry Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the School of Chemistry and Biochemistry
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Recent Submissions
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Parsing the Dual Roles of Cu/Zn Superoxide Dismutase (Sod1) in Oxidative Stress Protection and Redox Signaling
(Georgia Institute of Technology, 2021-01-04)Superoxide dismutases (SODs) are a highly conserved class of antioxidant enzymes that serve on the frontline of defense against reactive oxygen species (ROS). SODs, which detoxify superoxide radicals (O2•-) by catalyzing ... -
Electronic structure methods for studying non-covalent interactions in complex chemical environments
(Georgia Institute of Technology, 2020-04-28)Non-covalent interactions (NCI) encompass the quantum mechanical forces felt between atoms and molecules which are not directly bonded to one another. Responsible for governing diverse chemical and physical phenomena, NCI ... -
New Strategies in the Expression, Purification, and Reconstitution of the Cystic Fibrosis Transmembrane conductance Regulator for Biochemical and Biophysical Characterization in Different Lipid Environments
(Georgia Institute of Technology, 2020-01-10)Membrane proteins are difficult to study in solution due to the use of detergent to protect the hydrophobic portion of the protein that interacts with the fatty acid tails of the lipid bilayer. However, a recent technology ... -
Computational Analysis of the Structure and Noncovalent Interactions of Nucleic Acids and their Analogs
(Georgia Institute of Technology, 2021-04-30)In recent years, no event has been more consequential than the emergence of the Covid-19 pandemic. Covid-19 has disrupted the globe at an unprecedented scale and has caused profound changes to our daily lives. Our inability ... -
DISCOVERY OF NOVEL DRUGS WITH TISSUE AND CELL-TYPE SELECTIVITY FOR CANCER AND INFLAMMATION
(Georgia Institute of Technology, 2021-04-26)Uncontrolled inflammation is a key factor in multiple disease types, including tissue fibrosis and cancers. The underlying mechanisms and treatment of several of these diseases are still unsolved medical challenges. The ... -
Analysis of Adenosine Triphosphate in Spatially Distributed Planetary Analog Field Samples to Inform Biosignature Detection Missions
(Georgia Institute of Technology, 2021-05-11)New discoveries of potentially habitable environments elsewhere in our solar system, and at the extremes here on Earth, have reopened the imagination to possibilities for extraterrestrial life. Planetary field analog ... -
Copper-Based Nanocrystals and Their Use as Catalysts for the Electrochemical Reduction of Carbon Dioxide
(Georgia Institute of Technology, 2020-12-06)Benefiting from the high abundance, low price, and fascinating properties of copper (Cu), Cu and Cu-based nanocrystals have found wide-spread use in many applications. In recent years, they received increasing attention ... -
PARSIMONIOUS ALGORITHMS AND IMPLEMENTATION IN QUANTUM CHEMISTRY
(Georgia Institute of Technology, 2020-12-07)The fundamental crux affecting the performance of quantum chemistry calculations is the need to cover a large number of terms in a way that may entail managing a large amount of data. The costs in time and storage associated ... -
Replication and kinetic trapping of nucleic acids in alternative environments
(Georgia Institute of Technology, 2020-12-06)Many hypotheses in origins of life research state that informational polymers likely appeared before coded protein enzymes, which could have had a specific catalytic function. Replication of these polymers is a process ... -
SURFACE MODIFICATION OF HARD PVC BY MOLECULES WITH ANTIBACTERIAL ACTIVITY
(Georgia Institute of Technology, 2019-12-09)In this work, we present an analysis of different PVC surface modifications, attempted with the intention of attaching antibacterial small molecules, polymers, and oligomers on the plastic. These modifications allowed us ... -
Crosslinked Polytriazoles toward Chemically Stable Separations Membranes
(Georgia Institute of Technology, 2019-11-08)Membranes have emerged as energy efficient molecular separation platforms relative to traditional energy-intensive processes in the fields of hydrocarbon separations and water desalination. However, membranes are seldom ... -
Understanding the Effects of Structure on the Charge Transport Properties and Doping of Dioxythiophene Polymers
(Georgia Institute of Technology, 2019-11-06)Redox-active conjugated polymers have been investigated for a multitude of applications including electrochromic displays, transistors, and transparent conducting electrodes. As with all fields of polymer science, the ... -
Probing Heme Trafficking Using Genetically Encoded Fluorescent Heme Sensors
(Georgia Institute of Technology, 2019-11-05)In this thesis, we describe genetic screens in Baker’s yeast to identify factors that regulate a. steady-state heme availability, b. the dynamics of heme mobilization to different subcellular compartments as it is being ... -
Non-canonical structures and functions of the human ribosome: G-quadruplexes and heme appropriation
(Georgia Institute of Technology, 2020-07-14)The ribosome is a macromolecular ribonucleoprotein machine that is responsible for the synthesis of all proteins in cells. Mammalian ribosomal RNAs (rRNAs) are nearly twice as large as those of prokaryotes. Differences in ... -
Monitoring morphology in organic photovoltaic blend systems
(Georgia Institute of Technology, 2020-06-09)Solution processed organic solar cells based on a bulk-heterojunction morphology have attracted attention as a promising source of energy, featuring materials that can be integrated into devices with the potential for ... -
Design and processing of charge transport polymer semiconductors and their applications in n-channel organic field effect transistors
(Georgia Institute of Technology, 2019-05-21)The molecular structures of polymeric semiconductors were strategically designed to impart electronic characteristics conducive to increasing electron-transport performance in organic field effect transistor devices. The ... -
Pigments of My Imagination: Controlling Color and Redox Properties in Conjugated Organic Electrochromic Materials
(Georgia Institute of Technology, 2019-05-21)The properties of 3,4-dioxythiophene (DOT)-based π-conjugated electrochromic polymers (ECPs) and molecules are explored with a focus on controlling structure-property relationships to achieve desired light absorption across ... -
Engineering elongation factor Tu and tRNAs to better accommodate non-canonical amino acids during translation
(Georgia Institute of Technology, 2018-07-26)Non-canonical amino acid (ncAA) incorporation has led to significant advances in protein science and engineering. Traditionally, incorporation of ncAAs is achieved via amber codon suppression using an engineered orthogonal ... -
Geometric, electronic and optical properties of organic charge transfer systems: Photovoltaic blends and donor-acceptor co-crystals
(Georgia Institute of Technology, 2020-04-03)Over the past two decades, π-conjugated organic molecules have found applications in the active layer of different types of organic electronic devices. To optimize and improve the performance of each of these devices, it ... -
Utilization of mass spectrometric techniques to identify novel lipid biomarkers of traumatic brain injury and other practical applications
(Georgia Institute of Technology, 2020-01-06)The primary focus of this thesis centers around the examination of lipids to aid in the diagnosis, prognosis, and mechanistic understanding of traumatic brain injury (TBI). Lipids are important signaling molecules and play ...
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