School of Chemistry and Biochemistry Theses and Dissertations
Original work in partial fulfillment of a graduate degree in the School of Chemistry and Biochemistry
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Recent Submissions
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Copper-Based Nanocrystals and Their Use as Catalysts for the Electrochemical Reduction of Carbon Dioxide
(Georgia Institute of Technology, 2020-12-06)Benefiting from the high abundance, low price, and fascinating properties of copper (Cu), Cu and Cu-based nanocrystals have found wide-spread use in many applications. In recent years, they received increasing attention ... -
PARSIMONIOUS ALGORITHMS AND IMPLEMENTATION IN QUANTUM CHEMISTRY
(Georgia Institute of Technology, 2020-12-07)The fundamental crux affecting the performance of quantum chemistry calculations is the need to cover a large number of terms in a way that may entail managing a large amount of data. The costs in time and storage associated ... -
Replication and kinetic trapping of nucleic acids in alternative environments
(Georgia Institute of Technology, 2020-12-06)Many hypotheses in origins of life research state that informational polymers likely appeared before coded protein enzymes, which could have had a specific catalytic function. Replication of these polymers is a process ... -
SURFACE MODIFICATION OF HARD PVC BY MOLECULES WITH ANTIBACTERIAL ACTIVITY
(Georgia Institute of Technology, 2019-12-09)In this work, we present an analysis of different PVC surface modifications, attempted with the intention of attaching antibacterial small molecules, polymers, and oligomers on the plastic. These modifications allowed us ... -
Crosslinked Polytriazoles toward Chemically Stable Separations Membranes
(Georgia Institute of Technology, 2019-11-08)Membranes have emerged as energy efficient molecular separation platforms relative to traditional energy-intensive processes in the fields of hydrocarbon separations and water desalination. However, membranes are seldom ... -
Understanding the Effects of Structure on the Charge Transport Properties and Doping of Dioxythiophene Polymers
(Georgia Institute of Technology, 2019-11-06)Redox-active conjugated polymers have been investigated for a multitude of applications including electrochromic displays, transistors, and transparent conducting electrodes. As with all fields of polymer science, the ... -
Probing Heme Trafficking Using Genetically Encoded Fluorescent Heme Sensors
(Georgia Institute of Technology, 2019-11-05)In this thesis, we describe genetic screens in Baker’s yeast to identify factors that regulate a. steady-state heme availability, b. the dynamics of heme mobilization to different subcellular compartments as it is being ... -
Non-canonical structures and functions of the human ribosome: G-quadruplexes and heme appropriation
(Georgia Institute of Technology, 2020-07-14)The ribosome is a macromolecular ribonucleoprotein machine that is responsible for the synthesis of all proteins in cells. Mammalian ribosomal RNAs (rRNAs) are nearly twice as large as those of prokaryotes. Differences in ... -
Monitoring morphology in organic photovoltaic blend systems
(Georgia Institute of Technology, 2020-06-09)Solution processed organic solar cells based on a bulk-heterojunction morphology have attracted attention as a promising source of energy, featuring materials that can be integrated into devices with the potential for ... -
Design and processing of charge transport polymer semiconductors and their applications in n-channel organic field effect transistors
(Georgia Institute of Technology, 2019-05-21)The molecular structures of polymeric semiconductors were strategically designed to impart electronic characteristics conducive to increasing electron-transport performance in organic field effect transistor devices. The ... -
Pigments of My Imagination: Controlling Color and Redox Properties in Conjugated Organic Electrochromic Materials
(Georgia Institute of Technology, 2019-05-21)The properties of 3,4-dioxythiophene (DOT)-based π-conjugated electrochromic polymers (ECPs) and molecules are explored with a focus on controlling structure-property relationships to achieve desired light absorption across ... -
Engineering elongation factor Tu and tRNAs to better accommodate non-canonical amino acids during translation
(Georgia Institute of Technology, 2018-07-26)Non-canonical amino acid (ncAA) incorporation has led to significant advances in protein science and engineering. Traditionally, incorporation of ncAAs is achieved via amber codon suppression using an engineered orthogonal ... -
Geometric, electronic and optical properties of organic charge transfer systems: Photovoltaic blends and donor-acceptor co-crystals
(Georgia Institute of Technology, 2020-04-03)Over the past two decades, π-conjugated organic molecules have found applications in the active layer of different types of organic electronic devices. To optimize and improve the performance of each of these devices, it ... -
Utilization of mass spectrometric techniques to identify novel lipid biomarkers of traumatic brain injury and other practical applications
(Georgia Institute of Technology, 2020-01-06)The primary focus of this thesis centers around the examination of lipids to aid in the diagnosis, prognosis, and mechanistic understanding of traumatic brain injury (TBI). Lipids are important signaling molecules and play ... -
Biosynthesis of the thiopetins and identification of an F420H2-dependent dehydropiperidine reductase
(Georgia Institute of Technology, 2019-05-21)Thiopeptins are highly decorated thiopeptide antibiotics similar in structure to thiostrepton A and harbor two unusual features. All thiopeptins contain a thioamide, a rare moiety among natural products, and a subset of ... -
Ligand design for developing f-element photochemistry
(Georgia Institute of Technology, 2019-04-30)Overall, this thesis describes the synthesis and characterization of ligand architectures to study f-element photochemistry. Chapter 1 provides a general overview of photocatalysis and uses and need to develop photochemistry ... -
Proton coupled electron transfer and structural dynamics in biomimetic beta hairpins
(Georgia Institute of Technology, 2019-03-29)Several crucial proteins required for the maintenance of life on earth utilize the potent oxidant of tyrosyl radical in their catalytic mechanism. This free radical species can have devastating effects, yet nature has ... -
Studies in using gold nanoparticles in treating cancer and inhibiting metastasis
(Georgia Institute of Technology, 2019-04-01)Based on statistics from the World Health Organization, cancer is among the top killers in the world. Metastasis, which is the process of cancer cells leaving their primary location and forming secondary tumor(s) in remote ... -
Redox-active organometallic dimers as dopants and surface modifiers in optoelectronics
(Georgia Institute of Technology, 2019-04-02)This dissertation focuses on the use of the dimers formed by some 19-electron organometallic sandwich compounds to tune the electronic properties of transparent conductive oxides, particularly indium tin oxide (ITO) and ... -
Development of conformational myocilin antibodies, and biophysical characterisation of the mouse myocilin olfactomedin domain
(Georgia Institute of Technology, 2019-04-02)Mutations in myocilin are causative for the heritable form of open angle glaucoma in humans yet, almost 20 years after its discovery, the function of myocilin within the trabecular meshwork (TM) eye remains elusive. In ...
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