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dc.contributor.advisorArvanitis, Costas
dc.contributor.authorDister, Jacqueline Faye
dc.date.accessioned2018-08-20T19:10:57Z
dc.date.available2018-08-20T19:10:57Z
dc.date.created2018-05
dc.date.submittedMay 2018
dc.identifier.urihttp://hdl.handle.net/1853/60368
dc.description.abstractThe purpose of this study is to analyze the effect of ultrasonic pressure on the mechanosensitive channel activity in the N2A cell line. Prior research has indicated that certain ion channels in the cellular membrane of the N2A cell line can be activated by the application of static pressure. Here, in addition to static pressure, we applied ultrasound pressure to the N2A cells, and assessed the effectiveness of these two stimuli using the patch-clamp method. Results indicate a positive correlation between the application of static pressure and the current response, confirming the piezo-electrical characteristics of these channels. Moreover, the resemblance between the response to static pressure and to that of ultrasound implicates the role of Piezo channels in high frequency mechanosensation and opens up many possibilities in the use of ultrasound for neuromodulation. Identifying the cell populations in the brain that express mechanosensitive channels could provide novel ultrasound-based therapies for neurodegenerative diseases.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectMechanosensation
dc.subjectPiezo
dc.subjectUltrasound
dc.subjectNeuromodulation
dc.subjectpatch-clamp
dc.subjectNeuroengineering
dc.titleMechanically Activated Currents in Mechanosensitive Cells
dc.typeUndergraduate Research Option Thesis
dc.description.degreeUndergraduate
dc.contributor.departmentBiomedical Engineering (Joint GT/Emory Department)
thesis.degree.levelUndergraduate
dc.contributor.committeeMemberYang, Bo
dc.contributor.committeeMemberVelalopoulou, Anastasia
dc.date.updated2018-08-20T19:10:57Z


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