• Mitochondrial Dysfunction in Chronic Limb Ischemic Myopathy 

  Kim, Do Young Young

  Critical limb ischemia (CLI), the most advanced clinical manifestation of peripheral arterial disease (PAD), is associated with cycles of ischemia and reperfusion (I/R) that are thought to compromise the bioenergetics of ...

• In-Situ Water Quality Monitoring for Resource-Constrained Areas 

  Johnson, Ann E

  Water-borne pathogens and unsafe water supplies are the cause of death for 1.7 million people every year [1]. Many of these people live in the developing world, where it can be difficult to manage water safety. The World ...

• Gastrointestinal Motility: Kinematic Properties of Segmentation Contraction 

  Lamarca, Morgan

  The kinematic processes of the small intestine play integral roles in overseeing the digestion and transportation of food throughout the gastrointestinal tract. Specifically responsible for governing the flow and digestion ...

• Catalytic abilities of the Schistosoma mansoni hammerhead ribozyme with mutated substrates in ice 

  Calvird, Audrey

  The synthesis of biomolecules in an environment similar to a pre-biotic Earth within the field of evolutionary chemistry has applications in understanding abiogenesis and the evolution of early biological systems on Earth. ...

• Generalizing Disease Associations to Non-Studied Populations 

  Patel, Kane

  This study determines whether risk allele frequencies (RAFs) for common diseases can be generalized in genome wide association surveys (GWAS) that are done in different populations other than the original study population. ...

• Genetics of Captive Naked Mole-Rat Populations 

  Groh, Amy M (Georgia Institute of Technology, 2015-06-30)

  The evolution of highly social behavior (eusociality) represents one of the major transition points in evolutionary history. Naked mole-rats (NMRs), Heterocephalus glaber, are one of the few known eusocial mammals, meaning ...

• Fish response to macroalgal removal 

  Lin, Cara

  Coral reefs are rapidly degrading into macroalgae dominated systems sustained through positive feedback loops. Macroalgae can harm corals directly via competition and indirectly via suppression of recruitment and increasing ...

• K-mer based data structures and heuristics for microbes and cancer 

  Huang, Cai (Georgia Institute of Technology, 2018-05-15)

  Recent technological advances allow for high throughput profiling of biological systems in a cost-efficient manner. The low cost of data generation is leading us to the “big data” era and the availability of big data ...

• Understanding pathways regulating liver versus pancreas fate decision and beta-cell regeneration 

  Xu, Jin (Georgia Institute of Technology, 2017-08-02)

  The liver and pancreas originate from common endodermal progenitors in early development. It has been shown that Bone morphogenetic protein 2b (Bmp2b) signaling is essential for determining the fate of these bipotential ...

• Applied bioinformatics for exploring diversity patterns in meta-omic data 

  Ranjan, Piyush (Georgia Institute of Technology, 2018-04-25)

  This thesis explores the utility of applied bioinformatic approaches to better understand sequence space and phylogenetic diversity in meta-omic clinical and environmental datasets. In three chapters, the thesis describes ...

• Investigating ice slurry’s perceived mechanical abrasive quality to increase pathogen reduction on poultry during immersion chilling 

  Richter, Stephanie (Georgia Institute of Technology, 2018-04-26)

  The poultry industry is an integral part of Georgia’s economy, accounting for more than half of the state’s agricultural output. In Georgia, more than 20 million pounds of broiler meat are produced daily. Poultry processing ...

• Individualization of the pubic hair/pubic area microbiome and its potential as an indicator of sexual contact 

  Williams, Diana Wagner (Georgia Institute of Technology, 2018-03-29)

  The microbiome, specifically the human microbiome, is an area of intense research with potential forensic applications. If the microbiome of a given body area is individualizing, then the transfer of microbiomes between ...

• Understanding the mechanisms and consequences of DSB induced by palindromic DNA sequences 

  Sheng, Ziwei (Georgia Institute of Technology, 2017-04-07)

  Palindromic DNA sequences, capable of forming hairpin or cruciform structures, are often a potent sources of genome instability by inducing double strand breakage (DSB). Studies on palindrome-induced instability have ...

• Discovery, characterization and mechanism of RNA and CDNA-mediated DNA double-strand break repair 

  Keskin, Havva (Georgia Institute of Technology, 2017-04-06)

  A double-strand break (DSB) is one of the most deleterious DNA lesions and its repair is crucial for genome stability. Even if a single DSB is not repaired precisely, this could cause mutations, chromosomal rearrangements, ...

• Genetics of type VI secretion and natural transformation in Vibrio cholerae 

  Watve, Samit S. (Georgia Institute of Technology, 2017-01-13)

  The facultative waterborne pathogen Vibrio cholerae transitions between its human host and the environment where it colonizes chitinous surfaces in aquatic settings. Growth on chitin coordinates the induction of sets of ...

• Structural analysis of virus assembly by cryo-electron tomography: Measles virus and respiratory syncytial virus 

  Ke, Zunlong (Georgia Institute of Technology, 2018-03-27)

  Viruses, are such efficient nano-machines that they can pack all the genomic materials in a confined space essential for self-replication; and yet they are the smallest of living entities among all life forms. When studied ...

• Competition for biotic resources and coexistence in variable environments 

  Jiang, Lin (Georgia Institute of Technology, 2009-12-01)

• Transposable element polymorphisms and human genome regulation 

  Wang, Lu (Georgia Institute of Technology, 2017-11-13)

  Transposable elements (TEs) are DNA sequences that are capable of moving from one genomic location to another. A large proportion of the human genome is derived from TEs, and TE-derived sequences have been shown to contribute ...

• Population genetics and genomics of eusocial animals 

  Chau, Linh M. (Georgia Institute of Technology, 2017-11-09)

  Major evolutionary transitions have been associated with increases in organismal complexity. One of the latest evolutionary transitions is from solitary life to eusociality. This transition led to a reproductive division ...

• Unrecognized diversity of microbes linking methanotrophy to nitrogen loss in marine oxygen minimum zones 

  Padilla, Cory Cruz (Georgia Institute of Technology, 2017-11-13)

  Methane (CH4) is a potent greenhouse gas with 25 times the warming potential of carbon dioxide (CO2) on a per mol basis. Marine oxygen minimum zones (OMZs) are enriched in CH4 compared to oxygenated water columns and are ...

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