• Novel Microbial Platform for Degradation of Hazardous Organic Contaminants and Production of Sustainable Bioplastics 

  Sekar, Ramanan (Georgia Institute of Technology, 2016-04-15)

  Improper disposal of 1,4-dioxane and the chlorinated organic solvents trichloroethylene (TCE) and tetrachloroethylene (PCE) has resulted in widespread contamination of soil and groundwater. In the present study, a novel ...

• Population genomics of human polymorphic transposable elements 

  Rishishwar, Lavanya (Georgia Institute of Technology, 2016-11-15)

  Transposable element (TE) activity has had a major impact on the human genome; more than two-thirds of the sequence is derived from TE insertions. Several families of human TEs – primarily Alu, L1 and SVA – continue to ...

• Gene expression profiling approach towards enhancement of malaria vaccine development 

  Rojas Pena, Monica Lisseth (Georgia Institute of Technology, 2016-08-24)

  Malaria continues to be one of the highest morbidity and mortality infectious diseases in the world, posing an enormous public health burden with significant economic consequences. The development of vaccines that provide ...

• Moderately lower temperatures greatly extend the lifespan of Brachionus manjavacas (Rotifera): thermodynamics or gene regulation? 

  Johnston, Rachel Kelsey (Georgia Institute of Technology, 2015-11-20)

  Environmental temperature greatly affects lifespan in a wide variety of animals, but the exact mechanisms underlying this effect are still largely unknown. A moderate temperature decrease from 22°C to 16°C extends the ...

• INTERACTIVE EFFECTS OF DISTURBANCE AND DISPERSAL ON COMMUNITY ASSEMBLY 

  Bannister, Miriam Nozomi Ojima (Georgia Institute of Technology, 2015-11-18)

  The traditional debate on alternative community states has been over whether or not they exist. Recent studies have focused on the role of assembly history in dictating community divergence, but the context in which assembly ...

• RNA Ligation by Hammerhead Ribozymes and DNAzyme in Plausible Prebiotic Conditions 

  Lie, Lively (Georgia Institute of Technology, 2015-08-21)

  This work is focused on the ligation activity of the hammerhead ribozyme and DNAzymes in plausible prebiotic conditions. Before the Great Oxidation Event, RNA may have interacted with soluble Fe2+, as a replacement or in ...

• Natural competence and Type VI secretion in Vibrio cholerae 

  Bernardy, Eryn (Georgia Institute of Technology, 2016-07-22)

  The waterborne bacterium Vibrio cholerae, responsible for epidemics of cholera diarrhea, associates with the human gut and with chitinous surfaces in aquatic reservoirs. Prior studies of two clinical V. cholerae isolates ...

• Translational bioinformatics for personalized medicine and integrative biology: Data integration, extraction, knowledge discovery, and visualization 

  Uppal, Karan (Georgia Institute of Technology, 2015-10-13)

  This thesis focuses on developing a computational framework to support the Precision Medicine Initiative. The newly developed tools and algorithms use machine learning, text mining and visualization techniques for extracting ...

• Functional significance of sequence variation among miR-200/205 families of miRNAs in ovarian cancer 

  Jabbari, Neda (Georgia Institute of Technology, 2015-07-10)

  MicroRNAs are short non-coding RNAs that regulate large suites of target genes. A family of miRNAs known as the miR-200 is implicated in the epithelial-mesenchymal/ mesenchymal-epithelial transition (EMT/MET), a process ...

• Microbes in the atmosphere: prevalence, species composition, and relevance to cloud formatio 

  De Leon, Natasha Isabel (Georgia Institute of Technology, 2015-07-14)

  The composition and prevalence of microorganisms in the upper troposphere and their role in aerosol-cloud-precipitation interactions represent important, unresolved questions for biological and atmospheric sciences. Most ...

• Functional Analysis Of The Inhibition Of Topoisomerase II Alpha By Linker Histone H1 

  Hamdan, Hiba (Georgia Institute of Technology, 2014-07-02)

  In higher eukaryotes, DNA is progressively packaged into chromatin. In these varying levels of compaction, linker histone H1 is a key player for mediating chromatin folding. As a result, linker histone H1 is involved in ...

• Improving algorithms of gene prediction in prokaryotic genomes, metagenomes, and eukaryotic transcriptomes 

  Tang, Shiyuyun (Georgia Institute of Technology, 2016-04-04)

  Next-generation sequencing has generated enormous amount of DNA and RNA sequences that potentially carry volumes of genetic information, e.g. protein-coding genes. The thesis is divided into three main parts describing i) ...

• Epigenetics in social insects 

  Glastad, Karl M. (Georgia Institute of Technology, 2016-01-14)

  Virtually all multicellular organisms are capable of developing differently in response to environmental variation. At the molecular level, such developmental plasticity requires interpretation and perpetuation of ...

• The assembly of protist communities: Understanding drivers of historical contingency and causes and consequences of biodiversity 

  Pu, Zhichao (Georgia Institute of Technology, 2015-04-06)

  Understanding mechanisms regulating the assembly of ecological communities is a major goal of community ecology. I combined experimental and theoretical approaches to investigate the influences of various ecological factors ...

• Bacterial iron and manganese reduction driven by organic sulfur electron shuttles 

  Cooper, Rebecca Elizabeth (Georgia Institute of Technology, 2015-04-08)

  Dissimilatory metal-reducing bacteria (DMRB) play an important role in the biogeochemical cycling of metals. DMRB are unique in that they possess the ability to couple metal reduction with their metabolism. Microbial ...

• Role of linker histone H1 in epigenetic regulation of pluripotency genes and Hox genes 

  Zhang, Yunzhe (Georgia Institute of Technology, 2014-04-04)

  Linker histone H1 plays a key role in facilitating folding of higher order chromatin structure. Previous studies have shown that deletion of three somatic H1 subtypes together leads to embryonic lethality and that H1c/H1d/H1e ...

• From rivers to natural gas: The influence of allochthonous inputs on marine nitrogen fixation and the carbon cycle 

  Weber, Sarah C. (Georgia Institute of Technology, 2015-12-04)

  The Western Tropical North Atlantic (WTNA) was once thought to be a net source of carbon dioxide (CO₂) to the atmosphere, but recent studies have shown that this Amazon River influenced region may actually act as a net ...

• Sustainable tilapia feed derived from urban food waste 

  Chaddick, Justin Garrett (Georgia Institute of Technology, 2015-12-08)

  Finding an alternative to fishmeal and fish oil in animal feeds has been a topic of increasing interest due to the pressures being put on the ocean’s fisheries and the increasing world demand for animal protein. An ...

• Computational tools for the analysis of biological networks in plants 

  Das, Abhiram (Georgia Institute of Technology, 2015-08-20)

  This thesis presents research associated to phenotyping of plants by applying informatics techniques which includes databases, web technologies, image processing and feature measurements of 2D and 3D images. The thesis ...

• Transcriptomics of malaria host-pathogen interactions in primates 

  Lee, Kevin Joseph (Georgia Institute of Technology, 2014-08-21)

  Malaria is a pernicious disease that has greatly impacted and continues to affect the human population. While much research has been performed to understand the underlying nature of this disease, gaps in the knowledge-base ...

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