Now showing items 1-10 of 18
Comparative and functional genomic analysis of human and chimpanzee retrotransposon sequences
(Georgia Institute of Technology, 2007-06-25)
Transposable elements (TEs) are mobile DNA sequences that can move from one location to another in the genome. These elements encode regulatory features including transcriptional promotion and termination signals facilitating ...
Computational analyses of gene expression profiles of ovarian and pancreatic cancer
(Georgia Institute of Technology, 2013-07-16)
Cancer is a devastating disease for human society with thousands of deaths and estimated new cases every year around the globe. Intensive research efforts on understanding the disease progression and determining effective ...
Using Microarrays to Quantify Stress Responses in Natural Populations of Coral
(Georgia Institute of Technology, 2007-07-06)
Coral reefs are one of the world s most valuable ecosystems but are declining at an accelerating rate. Common stressors impacting coral health include elevated temperatures, changes in light intensity, sedimentation, and ...
Repression of Tat-transactived HIV-LTR directed gene expression by E1A 12S oncoprotein
(Georgia Institute of Technology, 1994-05)
TATA-dependent repression of human immunodeficiency virus Type-1 transcription by the Adenovirus E1A 243R oncoprotein
(Georgia Institute of Technology, 1996-01)
Computational analysis of gene expression in complex disease
(Georgia Institute of Technology, 2014-08-21)
Cardiovascular disease (CVD) causes 45% of on-duty firefighter fatalities, a high fraction even when compared to the risk of CVD found in other first-responder professions like police work and emergency medical services. ...
Comparative genomic and epigenomic analyses of human and non-human primate evolution
(Georgia Institute of Technology, 2013-08-23)
Primates are one of the best characterized phylogenies with vast amounts of comparative data available, including genomic sequences, gene expression, and epigenetic modifications. Thus, they provide an ideal system to study ...
Epigenetic regulation of the human genome by transposable elements
(Georgia Institute of Technology, 2010-07-07)
Nearly one half of the human genome is composed of transposable elements (TEs). Once dismissed as 'selfish' or 'junk' DNA, TEs have also been implicated in a numerous functions that serve the needs of their host genome. ...
Application of bioinformatics in studies of sphingolipid biosynthesis
(Georgia Institute of Technology, 2010-05-17)
The studies in this dissertation demonstrate that the gene expression pathway maps are useful tools to notice alteration in different branches of sphingolipid biosynthesis pathway based on microarray and other transcriptomic ...
Rare and common genetic variant associations with quantitative human phenotypes
(Georgia Institute of Technology, 2015-07-01)
This dissertation aims at investigating the association between genotypes and phenotypes in human. Both common and rare regulatory variants have been studied. The phenotypes include disease risk, clinical traits and gene ...