Now showing items 1-9 of 9
Unsupervised and semi-supervised training methods for eukaryotic gene prediction
(Georgia Institute of Technology, 2008-11-17)
This thesis describes new gene finding methods for eukaryotic gene prediction. The current methods for deriving model parameters for gene prediction algorithms are based on curated or experimentally validated set of genes ...
The evolutionary significance of DNA methylation in human genome
(Georgia Institute of Technology, 2013-10-28)
In eukaryotic genomes ranging from plants to mammals, DNA methylation is a major epigenetic modification of DNA by adding a methyl group exclusively to cytosine residuals. In mammalian genomes such as humans, these cytosine ...
Functional analysis of subtelomeric breakage motifs using yeast as a model organism
(Georgia Institute of Technology, 2011-05-24)
Genome wide studies have uncovered the existence of large-scale copy number variation (CNV) in the human genome. The human genome of different individuals was initially estimated to be 99.9% similar, but population studies ...
Improvement of ab initio methods of gene prediction in genomic and metagenomic sequences
(Georgia Institute of Technology, 2010-04-06)
A metagenome originated from a shotgun sequencing of a microbial community is a heterogeneous mixture of rather short sequences. A vast majority of microbial species in a given community (99%) are likely to be non-cultivable. ...
The generation and maintenance of diversity in a rapid adaptive radiation
(Georgia Institute of Technology, 2011-08-23)
The Lake Malawi cichlid fishes are a pre-eminent example of adaptive evolutionary radiation. The diversity of species (nearly 1000 extant) is mirrored by an array of variation in dozens of phenotypes (e.g. trophic morphology, ...
Determination of non-watson-crick base pair stability and development of a new method for mutation detection
(Georgia Institute of Technology, 1994-12)
Genetic and immunological studies of surface antigens of the nematode Caenorhabditis elegans
(Georgia Institute of Technology, 1987-08)
Genetic, serological, and biochemical analysis of surface antigen mutants of the nematode Caenorhabditis elegans that express hidden antigens
(Georgia Institute of Technology, 1989-05)
Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective
(Georgia Institute of Technology, 2011-06-23)
Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw ...