Treatment Repurposing using Literature-Related Discovery

Abstract

Treatment Repurposing is the application of an existing treatment to diseases or symptoms of interest other than the disease(s) or symptom(s) for which the treatment was developed (and used) initially. It includes, but goes well beyond, Drug Repurposing. The present monograph uses Literature-Related Discovery (LRD) to identify treatments that could be repurposed for diseases of interest. The LRD methodology for identifying candidate repurposable treatments is presented in detail, and illustrative examples are provided from a recent monograph on prevention and treatment of Alzheimer's Disease. The present monograph also contains an extensive Bibliography of the core Treatment Repurposing literature, as well as two novel taxonomies of this literature. One taxonomy uses text clustering to display the myriad categories (and their relationships) in this Treatment Repurposing literature, and the other taxonomy uses factor analysis to display the myriad categories/themes in the same literature.