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Investigations of the thermally induced helix coil transitions of synthetic DNA
(Georgia Institute of Technology, 1975-08)
Single-molecule biophysics of toehold-mediated strand displacement
(Georgia Institute of Technology, 2018-07-23)
This thesis focuses on three separate explorations into the nature of toehold-mediated strand displacement which is a reaction characterized by the swapping of one stably bound oligonucleotide for another. The first study ...
Using Mechanistic Modeling to Understand Non-Linear and Age-Dependent Effects of Genetic Factors
(Georgia Institute of Technology, 2015-08-31)
Differences in DNA sequence between two individuals or cells can cause diseases like autism and cancer. The McGrath lab is interested in understanding how changes in DNA lead to observable differences among individuals of ...
Revisiting and Repurposing the Double Helix
(Georgia Institute of Technology, 2020-08-31)
DNA is an iconic molecule that forms a double helical structure, providing the basis for genetic inheritance, and its physical properties have been studied for decades. In this talk, I will present evidence that sequence ...
Interaction of RNA polymerase with DNA
(Georgia Institute of Technology, 1982)
The Physics of Genes and the Promise of Personalized Medicine
(Georgia Institute of Technology, 2016-11-17)
The twenty-first century is poised to see dramatic advances in medicine. The rapid after water and oxygen, is the most famous molecule of life known. This is not surprising, as the eye-catching double helix of DNA carries ...
Theoretical and experimental investigations of short DNA restriction fragments
(Georgia Institute of Technology, 1983-08)
A study of conformational features of distamycin-DNA and netropsin-DNA complexes by Raman spectroscopy
(Georgia Institute of Technology, 1978-08)
The binding of antibiotics to DNA
(Georgia Institute of Technology, 1975)
Interaction of RNA polymerase with DNA sites
(Georgia Institute of Technology, 1980)