A Biophysical Model of Endothelial Cell Behavior during Cerebral Cavernous Malformation
Park, Dae Eun
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Cerebral Cavernous Malformations (CCMs) are a collection of enlarged blood vessels with irregular structure in the brain that are caused by a mutation in one of three genes, CCM-1, -2, or -3. For those with CCMs, the capillaries have a thinner and less elastic wall than normal, leading to leakage of blood vessels. Symptoms include seizures, paralysis, and sometimes hemorrhaging in the brain . With no current prevention for the disease, further research on the mechanisms of the development of cavernous malformation is needed. In this project, our goal was to develop an endothelial cell model to investigate collective behavior of cell affected by CCM.