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dc.contributor.advisorBommarius, Andreas S.
dc.contributor.authorRose, Harrison B.
dc.date.accessioned2019-05-29T13:59:38Z
dc.date.available2019-05-29T13:59:38Z
dc.date.created2018-05
dc.date.issued2018-04-05
dc.date.submittedMay 2018
dc.identifier.urihttp://hdl.handle.net/1853/61151
dc.description.abstractThis research project explored the selection and development of an enzymatic route from the renewable feedstocks furfural and carbon dioxide to 2,5-furandicarboxylic acid, a building block for bio-based polyesters. A putative prenylated flavin-dependent reversible decarboxylase was identified as the most reasonable biocatalyst choice, although it was not isolated in a stable and active form in this work. To support future reaction engineering endeavors, this project also included studies of the aqueous liquid and solid solubility relationships between the reactive pathway intermediates and possible side products: furfural, 2 furancarboxylic acid, 5-formyl-2-furancarboxylic acid, and 2,5-furandicarboxylic acid. Finally, this work included an exploration into the mathematics of pH equilibria in aqueous reaction systems. These mathematical techniques were used to develop tools for assessing such systems by both colorimetric and calorimetric methods.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subject2,5-furandicarboxylic acid
dc.subjectpH equilibria
dc.subjectBiocatalysis
dc.titleTowards an enzymatic route to 2,5-furandicarboxylic acid
dc.typeDissertation
dc.description.degreePh.D.
dc.contributor.departmentChemical and Biomolecular Engineering
thesis.degree.levelDoctoral
dc.contributor.committeeMemberRealff, Matthew J.
dc.contributor.committeeMemberJones, Christopher W.
dc.contributor.committeeMemberFinn, M. G.
dc.contributor.committeeMemberSadowski, Gabriele
dc.date.updated2019-05-29T13:59:38Z


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