Assessment of Resting State Functional Connectivity in an Animal Model Using Optical Intrinsic Imaging
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In this investigation, the effects of mild closed head injury (cHI) on resting state functional connectivity (RSFC) were observed. Resting state changes in oxy- and deoxy hemoglobin (HbO, and HbR, respectively) concentrations were measured with optical intrinsic signaling (OIS). After planned imaging of four mice sham mice, and five injured mice, we were unable to analyze data for the complete population due to hard drive issues. However, data for Mouse 1, which was a sham-injured mouse, was preserved and analyzed. According to pilot data, our findings suggested that mice that are subject to cHI show a decrease in the area of the observed brain region, as well as a decrease in correlation, as reflected by the coefficient. Because of unforeseen issues with anesthetic availability, data storage, and technical concerns, the findings are not conclusive.