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dc.contributor.advisorPerreault, Marie-Claude
dc.contributor.authorBumgardner, Luke
dc.date.accessioned2019-05-30T16:23:54Z
dc.date.available2019-05-30T16:23:54Z
dc.date.created2019-05
dc.date.submittedMay 2019
dc.identifier.urihttp://hdl.handle.net/1853/61388
dc.description.abstractDescending serotonergic (5-HT) neurons located in the brainstem are known to influence mammalian locomotion. Neonates have poorer locomotor abilities than adults. Theoretically, a lesser contribution from 5-HT descending neurons in neonates is possible. However, a detailed quantification of 5-HT descending neurons in the neonate has yet to be performed. In this study, we quantify 5-HT descending neurons in each caudal raphe nuclei of the brainstem in the neonatal Pet1-GCaMP6 mouse (P1-P2). Descending 5-HT neurons were present in only three raphe nuclei, the raphe magnus (RMg), the raphe pallidus (RPa), and the raphe obscurus (ROB). Results show that 11% of all 5-HT neurons present in these nuclei project down the brainstem into the spinal cord. The largest majority of 5-HT descending neurons was found in the raphe pallidus (RPa), followed by the raphe magnus (RMg) nuclei, and finally, the raphe obscurus (ROB) nuclei.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectRaphe nuclei
dc.subjectSerotonergic neurons
dc.subject5-HT
dc.subjectRetrograde labelling
dc.subjectSpinal cord
dc.subjectControl of movement
dc.titleSpatial Distribution of Serotonergic Raphespinal Neurons in the Neonatal Mouse Brainstem
dc.typeUndergraduate Research Option Thesis
dc.description.degreeUndergraduate
dc.contributor.departmentBiomedical Engineering (Joint GT/Emory Department)
thesis.degree.levelUndergraduate
dc.contributor.committeeMemberHochman, Shawn
dc.date.updated2019-05-30T16:23:54Z


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