Perturbation-imaging Approaches to Study Functional Contributions of Cortical Activity to Human Movement
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The ability to learn and produce skilled movements is required for humans to successfully engage with each other and their environment. A principal role of the brain is to guide current, and plan future, movements based on past actions and potential rewards. In this talk, I will describe ongoing work in our lab employing multiple approaches to investigate the functional contributions of brain activity to normal and abnormal human movement. I will discuss how transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation, can be used both characterize and modulate cortical activity and connectivity during movement. I will also describe our recent findings showing abnormal TMS-evoked cortical reactivity post-stroke that is related to persistent paretic arm impairment. Lastly, I will discuss preliminary work applying alternative perturbation paradigms to study brain-behavior relationships in health and disease.