• Login
    View Item 
    •   SMARTech Home
    • Georgia Tech Theses and Dissertations
    • Georgia Tech Theses and Dissertations
    • View Item
    •   SMARTech Home
    • Georgia Tech Theses and Dissertations
    • Georgia Tech Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    A novel device for precise training and perturbing of motor cortically driven forelimb behaviors in the rat

    Thumbnail
    View/Open
    CORSTEN-THESIS-2018.pdf (29.20Mb)
    Date
    2018-12-10
    Author
    Corsten, Anthony Nicholas
    Metadata
    Show full item record
    Abstract
    Compared to humans and non-human primates, the rat is a promising model for studying the motor cortex during structured behavioral tasks due to its low cost and rapid trainability. However, options for behavioral tools for investigating motor cortically driven forelimb behaviors are limited. Here, we developed a one-dimensional rotation manipulandum for rat forelimb supination training that has low-latency, high-resolution detection of holding and turning. Additionally, we characterized the system to accurately produce a range of torques that could be used to dynamically perturb rodent forelimb rotation behavior with high precision. Following characterization, we validated the behavioral device using two behavioral paradigms, a static holding task and a knob turning task with virtual stiffness. Rats trained on the static holding task saw significant increases in their holding durations, while those trained on the knob turning task had significantly decreased peak turning angles as motor torque was increased. This end-to-end characterization showed our device to be effective at training and perturbing multiple potentially motor cortically driven behaviors. Ultimately, we hope to use this tool to uncover evidence of a dynamical system in rat motor cortex, like those already discovered in humans and monkeys.
    URI
    http://hdl.handle.net/1853/62247
    Collections
    • Department of Biomedical Engineering Theses and Dissertations [575]
    • Georgia Tech Theses and Dissertations [23877]

    Browse

    All of SMARTechCommunities & CollectionsDatesAuthorsTitlesSubjectsTypesThis CollectionDatesAuthorsTitlesSubjectsTypes

    My SMARTech

    Login

    Statistics

    View Usage StatisticsView Google Analytics Statistics
    facebook instagram twitter youtube
    • My Account
    • Contact us
    • Directory
    • Campus Map
    • Support/Give
    • Library Accessibility
      • About SMARTech
      • SMARTech Terms of Use
    Georgia Tech Library266 4th Street NW, Atlanta, GA 30332
    404.894.4500
    • Emergency Information
    • Legal and Privacy Information
    • Human Trafficking Notice
    • Accessibility
    • Accountability
    • Accreditation
    • Employment
    © 2020 Georgia Institute of Technology