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dc.contributor.authorO'Connor, Daniel
dc.date.accessioned2020-02-05T19:18:17Z
dc.date.available2020-02-05T19:18:17Z
dc.date.issued2020-01-27
dc.identifier.urihttp://hdl.handle.net/1853/62421
dc.descriptionPresented on January 27, 2020 at 11:15 a.m. in the Krone Engineered Biosystems Building, Room 1005.en_US
dc.descriptionDr. Daniel O’Connor is an associate professor of neuroscience at the Johns Hopkins University School of Medicine. His research focuses on neural circuits for touch perception and his lab is working to reveal the neural circuit foundations of sensory perception and provide a framework to understand how circuit dysfunction causes mental and behavioral aspects of neuropsychiatric illness.en_US
dc.descriptionRuntime: 54:33 minutesen_US
dc.description.abstractDaniel O'Connor discusses his laboratory’s recent work on the sensorimotor control of complex tongue movements. The brain generates complex sequences of movements that can be flexibly reconfigured in real-time based on sensory feedback, but how this occurs is not fully understood. They developed a novel ‘sequence licking’ task in which mice directed their tongue to a target that moved through a series of locations. Mice could rapidly reconfigure the sequence online based on tactile feedback. Closed-loop optogenetics and electrophysiology revealed that tongue/jaw regions of somatosensory (S1TJ) and motor (M1TJ) cortex encoded and controlled tongue kinematics at the level of individual licks. Tongue premotor (anterolateral motor, ALM) cortex encoded intended tongue angle in a smooth manner that spanned individual licks and even whole sequences, and progress toward the reward that marked successful sequence execution. ALM activity regulated sequence initiation, but multiple cortical areas collectively controlled termination of licking. Their results define a functional cortical network for hierarchical control of sensory- and reward-guided orofacial sequence generation.en_US
dc.format.extent54:33 minutes
dc.language.isoen_USen_US
dc.relation.ispartofseriesGT Neuro Seminar Seriesen_US
dc.subjectCortexen_US
dc.subjectMotor controlen_US
dc.subjectTongueen_US
dc.titleA Functional Cortical Network for Sensorimotor Sequence Generationen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Neural Engineering Centeren_US
dc.contributor.corporatenameJohns Hopkins University. School of Medicineen_US


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