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dc.contributor.authorRowan, Matthew
dc.date.accessioned2020-02-24T18:50:53Z
dc.date.available2020-02-24T18:50:53Z
dc.date.issued2020-02-17
dc.identifier.urihttp://hdl.handle.net/1853/62469
dc.descriptionPresented on February 17, 2020 at 11:15 a.m. in the Marcus Nanotechnology Building, Room 1116.en_US
dc.descriptionMatthew Rowan is an assistant professor at Emory University's School of Medicine. His lab uses a combination of cutting-edge imaging, electrophysiological, optogenetic, and surgical techniques to answer fundamental questions about brain function. Our research aims to uncover how the functional properties of neurons allow for proper learning and behavior, with an emphasis on electrical and chemical signaling within the smallest regions of these cells (dendritic spines and axonal boutons).en_US
dc.descriptionRuntime: 54:12 minutesen_US
dc.description.abstractHow do neurons perform the set of signaling functions necessary for proper circuit function? We aim to uncover cellular and molecular mechanisms that shape excitability among different mammalian neurons. We approach these questions in intact brain circuits, using intersectional approaches combining optogenetics, in vivo and ex vivo electrophysiology, 2P imaging, AAV vectors, and transgenic models. Perhaps the most critical neuronal signaling features are action potential firing and synaptic transmission. Neurons regulate these features by spatially segregating different ion channels in the soma, dendrites, and axon. We are now beginning to understand the significance of these cellular processes in terms of circuit function and disease. We are interested in understanding how different cell classes, (e.g., inhibitory neurons) utilize these excitable mechanisms to their advantage in the circuit. Knowledge gained from these studies will fuel the design of robust, cell-type-specific therapeutic approaches against neurological disorders.en_US
dc.format.extent54:12 minutes
dc.language.isoen_USen_US
dc.relation.ispartofseriesGT Neuro Seminar Seriesen_US
dc.subjectCortexen_US
dc.subjectDendriteen_US
dc.subjectInhibitionen_US
dc.titleDissection of Neural Circuit Function and Degeneration from a Subcellular Perspectiveen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Neural Engineering Centeren_US
dc.contributor.corporatenameEmory University. Dept. of Cell Biologyen_US


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