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    Molecular transport into the outer membrane of gram-negative bacteria

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    LUNDQUIST-DISSERTATION-2019.pdf (31.11Mb)
    Date
    2019-01-15
    Author
    Lundquist, Karl Philip
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    Abstract
    This thesis details novel insights gleaned from the application of molecular dynamics (MD) simulations to two protein systems, the $\beta$-barrel assembly machinery (BAM), and the lipopolysaccharide transport machinery (LPT) involved in the transport of vital molecular components of the outer membrane of Gram-negative bacteria. Through the subsequent chapters we discuss the revelation of key insights into the function of these molecular machines. We reveal that the central member of the $\beta$-barrel assembly machinery requires a kinked C-terminal strand for proper function. We also describe differences in the extent of dynamics of the $\beta$-barrel assembly machinery dependent on the conformations state and presence of a key protein member. Finally, we highlight important features of the lipopolysaccharide transport machinery governing the proper transport of the foremost protective element of Gram-negative bacteria.
    URI
    http://hdl.handle.net/1853/62643
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    • Georgia Tech Theses and Dissertations [23877]
    • School of Physics Theses and Dissertations [621]

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