Show simple item record

dc.contributor.advisorGumbart, James C.
dc.contributor.authorLundquist, Karl Philip
dc.date.accessioned2020-05-20T16:47:59Z
dc.date.available2020-05-20T16:47:59Z
dc.date.created2019-05
dc.date.issued2019-01-15
dc.date.submittedMay 2019
dc.identifier.urihttp://hdl.handle.net/1853/62643
dc.description.abstractThis thesis details novel insights gleaned from the application of molecular dynamics (MD) simulations to two protein systems, the $\beta$-barrel assembly machinery (BAM), and the lipopolysaccharide transport machinery (LPT) involved in the transport of vital molecular components of the outer membrane of Gram-negative bacteria. Through the subsequent chapters we discuss the revelation of key insights into the function of these molecular machines. We reveal that the central member of the $\beta$-barrel assembly machinery requires a kinked C-terminal strand for proper function. We also describe differences in the extent of dynamics of the $\beta$-barrel assembly machinery dependent on the conformations state and presence of a key protein member. Finally, we highlight important features of the lipopolysaccharide transport machinery governing the proper transport of the foremost protective element of Gram-negative bacteria.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectMolecular dynamics beta-barrel assembly protein structure outer membrane
dc.titleMolecular transport into the outer membrane of gram-negative bacteria
dc.typeDissertation
dc.description.degreePh.D.
dc.contributor.departmentPhysics
thesis.degree.levelDoctoral
dc.contributor.committeeMemberSponberg, Simon
dc.contributor.committeeMemberSchmidt-Krey, Ingeborg
dc.contributor.committeeMemberBarry, Bridgette
dc.contributor.committeeMemberNoinaj, Nicholas
dc.date.updated2020-05-20T16:47:59Z


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record