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dc.contributor.advisorMargulies, Susan
dc.contributor.authorLee, Ye Lim
dc.date.accessioned2021-03-08T16:57:34Z
dc.date.available2021-03-08T16:57:34Z
dc.date.created2018-12
dc.date.submittedDecember 2018
dc.identifier.urihttp://hdl.handle.net/1853/64352
dc.description.abstractThe method to identify and isolate the proteins is one of the keys to the immunoassay production. However, currently there is no effective way to isolate the protein not only because of limited number of technologies for protein detection but also the existing technologies have downfall of low sensitivity for protein detection and the secreted protein cross-reactivity. The present paper demonstrates the isolation and collection ability of the Janus particle. The study demonstrates the creation of Janus particle with one side of the particle targets and binds plasma cells while the other side contains protein G that collects specific antibodies that are secreted. Experiments were conducted to determine the ability of 2 μm and 4 μm size Janus Particle. Moreover, the study was carried out with hybridoma cells to determine whether the Janus particle can bind to the plasma B cell and collect antibody with another hemisphere.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technology
dc.subjectJanus Particle
dc.subjectIsolation
dc.subjectHybridoma Cells
dc.subjectProtein
dc.subjectSecretion
dc.subjectAntibody
dc.titleAbility of Janus Particle as Single Cell Sensor to Immobilize Plasma Cells and Collect Antibody
dc.typeUndergraduate Research Option Thesis
dc.description.degreeUndergraduate
dc.contributor.departmentBiomedical Engineering (Joint GT/Emory Department)
thesis.degree.levelUndergraduate
dc.date.updated2021-03-08T16:57:34Z


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